2'-5' oligoadenylate synthetase 1A (Q21436584)

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mammalian protein found in Mus musculus

(2-5')oligo(A) synthase 1A
2-5A synthetase 1A
(2-5')oligo(A) synthetase 1A
2-5A synthase 1A
p42 OAS
Oas1a
2'-5'-oligoadenylate synthase 1A

Language	Label	Description	Also known as
English	2'-5' oligoadenylate synthetase 1A	mammalian protein found in Mus musculus	(2-5')oligo(A) synthase 1A 2-5A synthetase 1A (2-5')oligo(A) synthetase 1A 2-5A synthase 1A p42 OAS Oas1a 2'-5'-oligoadenylate synthase 1A

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

2'-5'-oligoadenylate synthase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11928

2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Polymerase, nucleotidyl transferase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2-5-oligoadenylate synthetase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2-5-oligoadenylate synthetase, C-terminal conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

metal ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

protein binding

determination method or standard

3 references

14 February 2019

Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

double-stranded RNA binding

determination method or standard

6 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

2'-5'-oligoadenylate synthetase activity

determination method or standard

7 references

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

27 March 2018

A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

2'-5'-oligoadenylate synthetase activity

determination method or standard

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

double-stranded RNA binding

determination method or standard

7 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

intracellular membrane-bounded organelle

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

endoplasmic reticulum

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

determination method or standard

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11928&geneProductId=UniProtKB:P11928

determination method or standard

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

biological process

purine nucleotide biosynthetic process

determination method or standard

negative regulation of viral process

determination method or standard

1 reference

14 February 2019

A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

immune system process

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

response to virus

determination method or standard

1 reference

14 February 2019

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

immune response

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

innate immune response

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

negative regulation of viral genome replication

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

defense response to virus

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

regulation of ribonuclease activity

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11928

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000079198

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000079198

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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