Afadin, adherens junction formation factor (Q21172887)

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mammalian protein found in Homo sapiens

afadin
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
ALL1-fused gene from chromosome 6 protein
protein AF-6
AFDN

Language	Label	Description	Also known as
English	Afadin, adherens junction formation factor	mammalian protein found in Homo sapiens	afadin myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 ALL1-fused gene from chromosome 6 protein protein AF-6 AFDN

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

SMAD/FHA domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

Dilute domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ras-associating (RA) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Afadin, cargo binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Forkhead-associated (FHA) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein C-terminus binding

determination method

1 reference

8 April 2019

Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

protein binding

determination method

5 references

8 April 2019

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

8 April 2019

Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

8 April 2019

Regulation of c-Src by binding to the PDZ domain of AF-6

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

8 April 2019

Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

8 April 2019

EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

cadherin binding

determination method

1 reference

27 March 2018

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P55196&geneProductId=UniProtKB:P55196

determination method

cadherin binding

determination method

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

cell adhesion molecule binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

actin filament binding

determination method

1 reference

8 April 2019

Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

adherens junction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

plasma membrane

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

cell-cell contact zone

determination method

1 reference

8 April 2019

Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

tight junctions

determination method

1 reference

8 April 2019

EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

biological process

cell-cell signaling

determination method

1 reference

8 April 2019

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

establishment of endothelial intestinal barrier

determination method

1 reference

8 April 2019

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

regulation of protein localization

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

positive regulation of cell-cell adhesion

determination method

1 reference

8 April 2019

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

negative regulation of cell migration

determination method

1 reference

8 April 2019

Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

adherens junction organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

cell-cell adhesion mediated by cadherin

determination method

1 reference

8 April 2019

Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

establishment of protein localization to plasma membrane

determination method

1 reference

8 April 2019

Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

bicellular tight junction assembly

determination method

1 reference

8 April 2019

EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

positive regulation of cell-cell adhesion mediated by cadherin

determination method

1 reference

8 April 2019

Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55196

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

forkhead-associated (FHA) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

Ras-associating (RA) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

Afadin, cargo binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P55196

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000375956

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375956

ENSP00000375960

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375960

ENSP00000383623

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000383623

ENSP00000404595

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404595

ENSP00000252692

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000252692

ENSP00000341118

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000341118

ENSP00000355771

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355771

ENSP00000383625

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000383625

ENSP00000383626

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000383626

ENSP00000414675

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414675

ENSP00000421441

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421441

ENSP00000422166

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422166

ENSP00000423035

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423035

ENSP00000424188

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424188

ENSP00000426462

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000426462

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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