Mitogen-activated protein kinase kinase kinase 14 (Q21154955)

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mammalian protein found in Homo sapiens

• HsNIK
• Serine/threonine-protein kinase NIK
• NF-kappa-beta-inducing kinase
• MAP3K14

edit

Language	Label	Description	Also known as
English	Mitogen-activated protein kinase kinase kinase 14	mammalian protein found in Homo sapiens	HsNIK Serine/threonine-protein kinase NIK NF-kappa-beta-inducing kinase MAP3K14

Statements

instance of

protein

0 references

part of

mitogen-activated protein (MAP) kinase kinase kinase 14

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99558

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99558

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

1 December 2016

UniProt protein ID

Q99558

encoded by

MAP3K14

1 reference

stated in

NCBI Gene

retrieved

17 December 2016

Entrez Gene ID

9020

molecular function

transferase activity

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

protein kinase activity

determination method or standard

IDA

IEA

3 references

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

retrieved

1 January 2018

stated in

TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IDA

nucleotide binding

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

NF-kappaB-inducing kinase activity

determination method or standard

ISS

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

ISS

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

protein binding

determination method or standard

IPI

13 references

retrieved

1 January 2018

stated in

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

retrieved

1 January 2018

stated in

TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IPI

MAP kinase kinase kinase activity

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

ATP binding

determination method or standard

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

kinase activity

determination method or standard

IEA

TAS

2 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

TAS

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

protein serine/threonine kinase activity

determination method or standard

EXP

IBA

IEA

3 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IBA

retrieved

1 January 2018

stated in

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

EXP

cell component

cytoplasm

determination method or standard

IBA

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IBA

fibrillar center

determination method or standard

IDA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IDA

nucleus

determination method or standard

IDA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IDA

cytosol

determination method or standard

IDA

TAS

2 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

TAS

retrieved

1 January 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IDA

intracellular membrane-bounded organelle

determination method or standard

IDA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IDA

biological process

phosphorylation

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

tumor necrosis factor-mediated signaling pathway

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

TAS

MAPK cascade

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

protein phosphorylation

determination method or standard

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

cellular response to mechanical stimulus

determination method or standard

IEP

1 reference

retrieved

1 January 2018

stated in

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEP

immune response

determination method or standard

ISS

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

ISS

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

IMP

1 reference

retrieved

16 July 2018

stated in

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99558&geneProductId=UniProtKB:Q99558

determination method or standard

IMP

I-kappaB kinase/NF-kappaB signaling

determination method or standard

ISS

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

ISS

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IEA

NIK/NF-kappaB signaling

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

TAS

regulation of mitotic cell cycle

determination method or standard

IBA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99558&geneProductId=UniProtKB:Q99558

determination method or standard

IBA

signal transduction

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IBA

stress-activated protein kinase signaling cascade

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IBA

activation of protein kinase activity

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IBA

regulation of apoptotic process

determination method or standard

IBA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99558&geneProductId=UniProtKB:Q99558

determination method or standard

IBA

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

IBA

IMP

2 references

retrieved

1 January 2018

stated in

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

GOA

curator

UniProt

UniProt protein ID

Q99558

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IMP

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99558

determination method or standard

IBA

has part(s)

serine/threonine-protein kinase, active site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99558

protein kinase, ATP binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99558

protein kinase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q99558

Identifiers

RefSeq protein ID

NP_003945

1 reference

stated in

NCBI Gene

retrieved

17 December 2016

Entrez Gene ID

NP_003945

XP_011523743

1 reference

stated in

NCBI Gene

retrieved

17 December 2016

Entrez Gene ID

XP_011523743

UniProt protein ID

Q99558

1 reference

stated in

UniProt

retrieved

1 December 2016

UniProt protein ID

Q99558

PDB structure ID

4DN5

1 reference

stated in

UniProt

UniProt protein ID

Q99558

retrieved

9 August 2016

language of work or name

English

4G3D

1 reference

stated in

UniProt

UniProt protein ID

Q99558

retrieved

9 August 2016

language of work or name

English

4IDT

1 reference

stated in

UniProt

UniProt protein ID

Q99558

retrieved

9 August 2016

language of work or name

English

4IDV

1 reference

stated in

UniProt

UniProt protein ID

Q99558

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21154955&oldid=2023032525"