Proprotein convertase subtilisin/kexin type 5 (Q21154237)

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mammalian protein found in Homo sapiens

proprotein convertase 6
Proprotein convertase 5
subtilisin/kexin-like protease PC5
PC6
PC5
prohormone convertase 5
proprotein convertase subtilisin/kexin type 5
protease PC6
PCSK5
hPC6
subtilase

Language	Label	Description	Also known as
English	Proprotein convertase subtilisin/kexin type 5	mammalian protein found in Homo sapiens	proprotein convertase 6 Proprotein convertase 5 subtilisin/kexin-like protease PC5 PC6 PC5 prohormone convertase 5 proprotein convertase subtilisin/kexin type 5 protease PC6 PCSK5 hPC6 subtilase

Statements

1 reference

13 November 2019

UniProt protein ID

peptidase S8, subtilisin-related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Galactose-binding-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Peptidase S8/S53 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Peptidase S8, pro-domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Peptidase S8, pro-domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Growth factor receptor domain 4, protein family

1 reference

based on heuristic

inferred from protein domain or family

Kexin/furin catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase ephrin type A/B receptor-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase S8, subtilisin, Ser-active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

P domain family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase S8, subtilisin, Asp-active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Furin-like repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase S8, subtilisin, His-active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

serine-type endopeptidase activity

determination method or standard

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92824&geneProductId=UniProtKB:Q92824

determination method or standard

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92824&geneProductId=UniProtKB:Q92824

determination method or standard

10 September 2018

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92824&geneProductId=UniProtKB:Q92824

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

serine-type peptidase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

endopeptidase activity

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

serine-type endopeptidase activity

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

integral component of membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

endomembrane system

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

determination method or standard

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92824&geneProductId=UniProtKB:Q92824

determination method or standard

Golgi apparatus

determination method or standard

secretory granule

determination method or standard

1 reference

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

trans-Golgi network

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

integral component of Golgi membrane

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

biological process

viral life cycle

determination method or standard

3 references

8 April 2019

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

female pregnancy

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

cell-cell signaling

determination method or standard

1 reference

8 April 2019

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

coronary vasculature development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

renin secretion into blood stream

determination method or standard

1 reference

8 April 2019

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

cardiac septum development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

determination of left/right symmetry

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

protein processing

determination method or standard

3 references

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92824&geneProductId=UniProtKB:Q92824

determination method or standard

10 September 2018

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92824&geneProductId=UniProtKB:Q92824

determination method or standard

10 September 2018

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92824&geneProductId=UniProtKB:Q92824

determination method or standard

signal peptide processing

determination method or standard

1 reference

8 April 2019

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

kidney development

determination method or standard

3 references

8 April 2019

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

embryonic skeletal system development

determination method or standard

3 references

8 April 2019

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

embryonic digestive tract development

determination method or standard

3 references

8 April 2019

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

regulation of lipoprotein lipase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

protein processing

determination method or standard

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

peptide hormone processing

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

nerve growth factor processing

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92824

determination method or standard

Peptidase S8, subtilisin, Asp-active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

peptidase S8/S53 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

tyrosine-protein kinase ephrin type A/B receptor-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

peptidase S8, subtilisin, His-active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Peptidase S8, pro-domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Growth factor receptor domain 4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Peptidase S8, subtilisin, Ser-active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Furin-like repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Kexin/furin catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92824

Identifiers

MeSH descriptor ID

subject named as

Proprotein Convertase 5

0 references

D08.811.277.656.300.760.648

0 references

D08.811.277.656.837.625

0 references

D08.811.277.656.959.350.648

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000365943

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000365943

ENSP00000446280

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446280

ENSP00000365958

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000365958

ENSP00000407239

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407239

ENSP00000411654

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411654

ENSP00000501224

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000501224

ENSP00000500971

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000500971

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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