Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells (Q21133953)

17 August 2022

Paolo E Porporato

Paolo E

Porporato

1 reference

17 August 2022

Olivier

Feron

Olivier Feron

1 reference

23082126

Christophe J De Saedeleer

17 August 2022

Christophe J

De Saedeleer

Christophe J De Saedeleer

1 reference

17 August 2022

Tamara

Copetti

Tamara Copetti

1 reference

17 August 2022

Julien

Verrax

Julien Verrax

1 reference

23082126

Creative Commons Attribution 4.0 International

17 August 2022

language of work or name

English

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publication date

2012

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0 references

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e46571

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start time

17 October 2012

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

19 March 2017

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Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells

19 March 2017

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

7 April 2017

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7 April 2017

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

7 April 2017

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Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

28 May 2017

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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

12 September 2017

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Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.

12 September 2017

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12 September 2017

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Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

12 September 2017

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Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment

12 September 2017

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NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

12 September 2017

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Development of HIF-1 inhibitors for cancer therapy

12 September 2017

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12 September 2017

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12 September 2017

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HIF-1 mediates the Warburg effect in clear cell renal carcinoma

12 September 2017

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Regulation of HIF-1alpha stability through S-nitrosylation

12 September 2017

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Mitochondria as signaling organelles in the vascular endothelium

12 September 2017

1 reference

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Protein detection using proximity-dependent DNA ligation assays.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Determination of subcutaneous tumor size in athymic (nude) mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Hydrophobic interactions stabilize the basigin-MCT1 complex

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474765

Mechanism of inhibition of FaDu hypopharyngeal carcinoma cell growth by tetraphenylphosphonium chloride

29 November 2018

1 reference

12 December 2020

Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy

1 reference

12 December 2020

Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy

1 reference

12 December 2020

Biological properties of the human colonic adenocarcinoma cell line SW 620 grown as a xenograft in the athymic mouse

1 reference

12 December 2020

Regulatory mechanisms in carbohydrate metabolism. IV. Pasteur effect and Crabtree effect in ascites tumor cells

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0046571

Identifiers

DOI

1 reference

ADS bibcode

2012PLoSO...746571D

0 references

1 reference

1 reference

23082126

1 reference