CEA cell adhesion molecule 5 (Q21132936)

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mammalian protein found in Homo sapiens

• carcinoembryonic antigen-related cell adhesion molecule 5
• meconium antigen 100
• CEACAM5
• Carcinoembryonic antigen
• carcinoembryonic antigen related cell adhesion molecule 5
• CEA
• CD66e

edit

Language	Label	Description	Also known as
English	CEA cell adhesion molecule 5	mammalian protein found in Homo sapiens	carcinoembryonic antigen-related cell adhesion molecule 5 meconium antigen 100 CEACAM5 Carcinoembryonic antigen carcinoembryonic antigen related cell adhesion molecule 5 CEA CD66e

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P06731

part of

Immunoglobulin-like fold

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P06731

Immunoglobulin-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P06731

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin subtype 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P06731

encoded by

CEACAM5

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P06731

molecular function

GPI anchor binding

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IMP

protein homodimerization activity

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

identical protein binding

determination method or standard

IPI

2 references

retrieved

26 September 2017

stated in

Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06731&geneProductId=UniProtKB:P06731

determination method or standard

IPI

retrieved

26 September 2017

stated in

Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06731&geneProductId=UniProtKB:P06731

determination method or standard

IPI

identical protein binding

determination method or standard

IDA

IPI

3 references

retrieved

8 April 2019

stated in

Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IPI

retrieved

8 April 2019

stated in

Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IPI

retrieved

8 April 2019

stated in

Diverse oligomeric states of CEACAM IgV domains

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

cell component

anchored component of membrane

determination method or standard

IEA

1 reference

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06731&geneProductId=UniProtKB:P06731

determination method or standard

IEA

basolateral plasma membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

integral component of plasma membrane

determination method or standard

IDA

TAS

2 references

retrieved

8 April 2019

stated in

Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

TAS

retrieved

8 April 2019

stated in

The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

extracellular exosome

determination method or standard

IDA

3 references

retrieved

26 September 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06731&geneProductId=UniProtKB:P06731

determination method or standard

IDA

retrieved

26 September 2017

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06731&geneProductId=UniProtKB:P06731

determination method or standard

IDA

retrieved

26 September 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06731&geneProductId=UniProtKB:P06731

determination method or standard

IDA

membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IEA

integral component of external side of plasma membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

extracellular region

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

TAS

plasma membrane

determination method or standard

IDA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

cell surface

determination method or standard

IC

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IEA

retrieved

8 April 2019

stated in

Expression of complementary DNA and genomic clones for carcinoembryonic antigen and nonspecific cross-reacting antigen in Chinese hamster ovary and mouse fibroblast cells and characterization of the membrane-expressed products

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

retrieved

8 April 2019

stated in

Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IC

apical plasma membrane

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IEA

retrieved

8 April 2019

stated in

Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

anchored component of membrane

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IEA

retrieved

8 April 2019

stated in

Expression of complementary DNA and genomic clones for carcinoembryonic antigen and nonspecific cross-reacting antigen in Chinese hamster ovary and mouse fibroblast cells and characterization of the membrane-expressed products

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

extracellular exosome

determination method or standard

HDA

2 references

retrieved

8 April 2019

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

HDA

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

HDA

biological process

homotypic cell-cell adhesion

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

negative regulation of apoptotic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

negative regulation of anoikis

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Human carcinoembryonic antigen functions as a general inhibitor of anoikis

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

negative regulation of myotube differentiation

determination method or standard

IDA

2 references

retrieved

8 April 2019

stated in

The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

retrieved

8 April 2019

stated in

Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IDA

C-terminal protein lipidation

determination method or standard

TAS

1 reference

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06731&geneProductId=UniProtKB:P06731

determination method or standard

TAS

leukocyte migration

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

TAS

apoptotic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IEA

cell adhesion

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IEA

homophilic cell adhesion via plasma membrane adhesion molecules

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IMP

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion

GOA

curator

UniProt

UniProt protein ID

P06731

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06731

determination method or standard

IMP

has part(s)

immunoglobulin-like domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P06731

immunoglobulin V-set domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P06731

immunoglobulin subtype 2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P06731

immunoglobulin subtype

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P06731

Identifiers

RefSeq protein ID

NP_001278413

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1048

NP_001295327

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1048

NP_004354

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1048

XP_011524624

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1048

XP_016881634

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1048

XP_016881635

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1048

UniProt protein ID

P06731

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P06731

Ensembl protein ID

ENSP00000221992

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000221992

ENSP00000381600

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000381600

ENSP00000385072

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000385072

ENSP00000468997

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000468997

ENSP00000473252

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000473252

ENSP00000480800

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000480800

ENSP00000482157

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000482157

ENSP00000482303

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000482303

Freebase ID

/m/02kfsv4

0 references

PDB structure ID

1E07

1 reference

stated in

UniProt

UniProt protein ID

P06731

retrieved

20 March 2016

language of work or name

English

2QSQ

1 reference

stated in

UniProt

UniProt protein ID

P06731

retrieved

20 March 2016

language of work or name

English

2QST

1 reference

stated in

UniProt

UniProt protein ID

P06731

retrieved

20 March 2016

language of work or name

English

2VER

1 reference

stated in

UniProt

UniProt protein ID

P06731

retrieved

20 March 2016

language of work or name

English

 

Sitelinks

Wikipedia(5 entries)

edit

• dewiki CD66e
• enwiki CEACAM5
• ruwiki CEACAM5
• ttwiki CEACAM5
• ukwiki CEACAM5

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21132936&oldid=2023018577"