Guanylate binding protein 1 (Q21132640)

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mammalian protein found in Homo sapiens

• guanine nucleotide-binding protein 1
• interferon-induced guanylate-binding protein 1
• huGBP-1
• GTP-binding protein 1
• guanylate binding protein 1, interferon-inducible, 67kDa
• GBP1
• GBP-1
• guanylate-binding protein 1

edit

Language	Label	Description	Also known as
English	Guanylate binding protein 1	mammalian protein found in Homo sapiens	guanine nucleotide-binding protein 1 interferon-induced guanylate-binding protein 1 huGBP-1 GTP-binding protein 1 guanylate binding protein 1, interferon-inducible, 67kDa GBP1 GBP-1 guanylate-binding protein 1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P32455

part of

Guanylate-binding protein, C-terminal domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P32455

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P32455

Guanylate-binding protein, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanylate-binding protein, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GB1/RHD3-type guanine nucleotide-binding (G) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanylate-binding protein/Atlastin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P32455

encoded by

GBP1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P32455

molecular function

nucleotide binding

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

Hsp90 protein binding

determination method or standard

IPI

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

spectrin binding

determination method or standard

IPI

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

protein binding

determination method or standard

IPI

2 references

retrieved

9 May 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

identical protein binding

determination method or standard

IPI

3 references

retrieved

9 May 2019

stated in

How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

retrieved

9 May 2019

stated in

Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal α-helices

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

retrieved

9 May 2019

stated in

The guanine cap of human guanylate-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

enzyme binding

determination method or standard

IPI

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

actin binding

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

hydrolase activity

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

cytokine binding

determination method or standard

IPI

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IPI

GTPase activity

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

8 April 2019

stated in

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

GTP binding

determination method or standard

IDA

IEA

TAS

4 references

retrieved

8 April 2019

stated in

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

8 April 2019

stated in

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

GDP binding

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

protein homodimerization activity

determination method or standard

IDA

2 references

retrieved

9 May 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

retrieved

9 May 2019

stated in

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

GTPase activity

determination method or standard

IBA

IDA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

9 May 2019

stated in

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IBA

GTP binding

determination method or standard

IBA

IDA

IEA

TAS

5 references

retrieved

9 May 2019

stated in

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

9 May 2019

stated in

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IBA

cell component

cytosol

determination method or standard

IDA

TAS

2 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

TAS

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

Golgi membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

plasma membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

extracellular region

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

cytoplasm

determination method or standard

IDA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

9 May 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

retrieved

9 May 2019

stated in

Unique features of different members of the human guanylate-binding protein family.

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

Golgi apparatus

determination method or standard

IDA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

retrieved

9 May 2019

stated in

Unique features of different members of the human guanylate-binding protein family.

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

vesicle membrane

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

actin cytoskeleton

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

cytoplasmic vesicle

determination method or standard

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IBA

biological process

immune system process

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

interferon-gamma-mediated signaling pathway

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

TAS

negative regulation of T cell receptor signaling pathway

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IMP

negative regulation of protein localization to plasma membrane

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IMP

defense response to virus

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEA

regulation of calcium-mediated signaling

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IMP

negative regulation of ERK1 and ERK2 cascade

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IMP

negative regulation of substrate adhesion-dependent cell spreading

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IMP

regulation of protein localization to plasma membrane

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IGI

protein homooligomerization

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

cellular response to interferon-gamma

determination method or standard

IDA

2 references

retrieved

8 April 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

retrieved

8 April 2019

stated in

Unique features of different members of the human guanylate-binding protein family.

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

cellular response to interleukin-1

determination method or standard

IEP

1 reference

retrieved

9 May 2019

stated in

Unique features of different members of the human guanylate-binding protein family.

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEP

cellular response to tumor necrosis factor

determination method or standard

IEP

1 reference

retrieved

9 May 2019

stated in

Unique features of different members of the human guanylate-binding protein family.

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IEP

protein localization to vacuole

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

cellular response to interferon-gamma

determination method or standard

IBA

IDA

3 references

retrieved

9 May 2019

stated in

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

retrieved

9 May 2019

stated in

Unique features of different members of the human guanylate-binding protein family.

GOA

curator

UniProt

UniProt protein ID

P32455

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32455

determination method or standard

IBA

has part(s)

GB1/RHD3-type guanine nucleotide-binding (G) domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P32455

Guanylate-binding protein/Atlastin, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P32455

Guanylate-binding protein, N-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P32455

Guanylate-binding protein, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P32455

Identifiers

RefSeq protein ID

NP_002044

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2633

XP_024302119

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2633

UniProt protein ID

P32455

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P32455

Ensembl protein ID

ENSP00000359504

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000359504

PDB structure ID

1DG3

1 reference

stated in

UniProt

UniProt protein ID

P32455

retrieved

9 August 2016

language of work or name

English

1F5N

1 reference

stated in

UniProt

UniProt protein ID

P32455

retrieved

9 August 2016

language of work or name

English

2B8W

1 reference

stated in

UniProt

UniProt protein ID

P32455

retrieved

9 August 2016

language of work or name

English

2B92

1 reference

stated in

UniProt

UniProt protein ID

P32455

retrieved

9 August 2016

language of work or name

English

2BC9

1 reference

stated in

UniProt

UniProt protein ID

P32455

retrieved

9 August 2016

language of work or name

English

2D4H

1 reference

stated in

UniProt

UniProt protein ID

P32455

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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