TNF receptor superfamily member 14 (Q21135813)

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mammalian protein found in Homo sapiens

• tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
• TNFRSF14
• tumor necrosis factor receptor superfamily member 14
• CD40-like protein
• TR2
• Tumor necrosis factor receptor-like 2
• herpes virus entry mediator A
• tumor necrosis factor receptor-like gene2
• Herpesvirus entry mediator A
• HveA
• HVEM

edit

Language	Label	Description	Also known as
English	TNF receptor superfamily member 14	mammalian protein found in Homo sapiens	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) TNFRSF14 tumor necrosis factor receptor superfamily member 14 CD40-like protein TR2 Tumor necrosis factor receptor-like 2 herpes virus entry mediator A tumor necrosis factor receptor-like gene2 Herpesvirus entry mediator A HveA HVEM

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q92956

part of

Tumour necrosis factor receptor 14

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q92956

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tumor necrosis factor receptor 14/UL144, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TNFR/NGFR cysteine-rich region, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q92956

encoded by

TNFRSF14

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q92956

molecular function

virus receptor activity

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q92956

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IEA

protein binding

determination method or standard

IPI

7 references

retrieved

1 January 2018

stated in

Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM

GOA

curator

UniProt

UniProt protein ID

Q92956

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

retrieved

1 January 2018

stated in

A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

retrieved

1 January 2018

stated in

LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

retrieved

1 January 2018

stated in

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

retrieved

1 January 2018

stated in

Unconventional ligand activation of herpesvirus entry mediator signals cell survival

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

retrieved

1 January 2018

stated in

ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

retrieved

1 January 2018

stated in

Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

tumor necrosis factor-activated receptor activity

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

TAS

ubiquitin protein ligase binding

determination method or standard

IPI

1 reference

retrieved

1 January 2018

stated in

A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains

GOA

curator

UniProt

UniProt protein ID

Q92956

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

cytokine binding

determination method or standard

IPI

1 reference

retrieved

1 January 2018

stated in

Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM

GOA

curator

UniProt

UniProt protein ID

Q92956

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IPI

cell component

integral component of membrane

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q92956

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IEA

membrane

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q92956

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IEA

plasma membrane

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

TAS

integral component of plasma membrane

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

external side of plasma membrane

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

biological process

regulation of apoptotic process

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

T cell costimulation

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

TAS

tumor necrosis factor-mediated signaling pathway

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

TAS

multicellular organism development

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

cell surface receptor signaling pathway

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

TAS

response to lipopolysaccharide

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

regulation of cell population proliferation

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

immune response

determination method or standard

TAS

1 reference

retrieved

1 January 2018

stated in

Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

TAS

apoptotic signaling pathway

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

viral entry into host cell

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IEA

inflammatory response

determination method or standard

IBA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

viral process

determination method or standard

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q92956

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IEA

negative regulation of alpha-beta T cell proliferation

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

defense response to Gram-negative bacterium

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

defense response to Gram-positive bacterium

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

positive regulation of T cell migration

determination method or standard

IBA

1 reference

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92956&geneProductId=UniProtKB:Q92956

determination method or standard

IBA

has part(s)

TNFR/NGFR cysteine-rich region

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q92956

Tumor necrosis factor receptor 14/UL144, N-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q92956

Identifiers

MeSH descriptor ID

D053240

subject named as

Receptors, Tumor Necrosis Factor, Member 14

0 references

MeSH tree code

D12.776.543.750.705.852.760.500

0 references

D12.776.543.750.830.850

0 references

RefSeq protein ID

NP_001284534

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8764

NP_003811

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8764

XP_006711082

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8764

XP_011540685

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8764

XP_016858207

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8764

XP_016858209

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8764

UniProt protein ID

Q92956

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q92956

Ensembl protein ID

ENSP00000347948

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000347948

ENSP00000478308

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000478308

ENSP00000486883

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000486883

ENSP00000486250

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000486250

ENSP00000485902

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000485902

ENSP00000399533

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000399533

ENSP00000415254

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000415254

ENSP00000487464

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000487464

ENSP00000386859

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386859

ENSP00000485884

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000485884

ENSP00000411854

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000411854

ENSP00000399292

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000399292

ENSP00000486304

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000486304

ENSP00000485988

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000485988

PDB structure ID

1JMA

1 reference

stated in

UniProt

UniProt protein ID

Q92956

retrieved

20 March 2016

language of work or name

English

2AW2

1 reference

stated in

UniProt

UniProt protein ID

Q92956

retrieved

20 March 2016

language of work or name

English

4FHQ

1 reference

stated in

UniProt

UniProt protein ID

Q92956

retrieved

20 March 2016

language of work or name

English

4RSU

1 reference

stated in

UniProt

UniProt protein ID

Q92956

retrieved

20 March 2016

language of work or name

English

UMLS CUI

C0531372

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

edit

Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21135813&oldid=2023026431"