ALG2 alpha-1,3/1,6-mannosyltransferase (Q21113862)

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mammalian protein found in Homo sapiens

• asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)
• asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog
• alpha-1,3-mannosyltransferase ALG2
• homolog of yeast ALG2
• ALG2
• asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)
• GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
• alpha-1,3/1,6-mannosyltransferase ALG2
• asparagine-linked glycosylation protein 2 homolog
• GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
• GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase

edit

Language	Label	Description	Also known as
English	ALG2 alpha-1,3/1,6-mannosyltransferase	mammalian protein found in Homo sapiens	asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog alpha-1,3-mannosyltransferase ALG2 homolog of yeast ALG2 ALG2 asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase) GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase alpha-1,3/1,6-mannosyltransferase ALG2 asparagine-linked glycosylation protein 2 homolog GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9H553

part of

Mannosyltransferase ALG2

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9H553

Glycosyltransferase subfamily 4-like, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glycosyl transferase, family 1

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9H553

encoded by

ALG2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9H553

molecular function

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

transferase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

protein N-terminus binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IPI

protein heterodimerization activity

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IPI

glycosyltransferase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

protein binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IPI

calcium-dependent protein binding

determination method or standard

IMP

IPI

4 references

retrieved

8 April 2019

stated in

Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IPI

retrieved

8 April 2019

stated in

ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IPI

retrieved

8 April 2019

stated in

The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IPI

retrieved

8 April 2019

stated in

The penta-EF-hand protein ALG-2 interacts with a region containing PxY repeats in Alix/AIP1, which is required for the subcellular punctate distribution of the amino-terminal truncation form of Alix/AIP1

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IMP

alpha-1,3-mannosyltransferase activity

determination method or standard

IDA

TAS

2 references

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H553&geneProductId=UniProtKB:Q9H553

determination method or standard

TAS

retrieved

26 September 2017

stated in

A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H553&geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

alpha-1,3-mannosyltransferase activity

determination method or standard

IBA

IDA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

TAS

retrieved

8 April 2019

stated in

A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IBA

cell component

cytoplasm

determination method or standard

IDA

5 references

retrieved

8 April 2019

stated in

Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

The penta-EF-hand protein ALG-2 interacts with a region containing PxY repeats in Alix/AIP1, which is required for the subcellular punctate distribution of the amino-terminal truncation form of Alix/AIP1

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

Muscle atrophy in transgenic mice expressing a human TSC1 transgene

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

integral component of membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

nucleus

determination method or standard

IDA

3 references

retrieved

8 April 2019

stated in

Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

membrane

determination method or standard

IDA

IEA

3 references

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H553&geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

retrieved

26 September 2017

stated in

Muscle atrophy in transgenic mice expressing a human TSC1 transgene

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H553&geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

26 September 2017

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H553&geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

perinuclear region of cytoplasm

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

endoplasmic reticulum membrane

determination method or standard

IBA

TAS

2 references

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H553&geneProductId=UniProtKB:Q9H553

determination method or standard

TAS

retrieved

26 September 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H553&geneProductId=UniProtKB:Q9H553

determination method or standard

IBA

endoplasmic reticulum membrane

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

TAS

cytosol

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

actin cytoskeleton

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

membrane

determination method or standard

HDA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

retrieved

8 April 2019

stated in

Muscle atrophy in transgenic mice expressing a human TSC1 transgene

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

HDA

biological process

response to calcium ion

determination method or standard

IDA

2 references

retrieved

8 April 2019

stated in

ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

retrieved

8 April 2019

stated in

The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IDA

protein glycosylation

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

dolichol-linked oligosaccharide biosynthetic process

determination method or standard

IGI

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

TAS

retrieved

8 April 2019

stated in

A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis

GOA

curator

UniProt

UniProt protein ID

Q9H553

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IGI

mannosylation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IEA

oligosaccharide-lipid intermediate biosynthetic process

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H553

determination method or standard

IBA

has part(s)

Glycosyl transferase, family 1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9H553

Glycosyltransferase subfamily 4-like, N-terminal domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9H553

Identifiers

RefSeq protein ID

NP_149078

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

85365

UniProt protein ID

Q9H553

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9H553

Ensembl protein ID

ENSP00000326609

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000326609

ENSP00000417764

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000417764

ENSP00000432675

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000432675

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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