Cholinergic receptor, nicotinic, alpha polypeptide 7 (Q21111177)

Neurotransmitter-gated ion-channel transmembrane domain superfamily

1 reference

Nicotinic acetylcholine receptor

1 reference

Neurotransmitter-gated ion-channel transmembrane domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neurotransmitter-gated ion-channel ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Neurotransmitter-gated ion-channel, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 August 2016

extracellular ligand-gated ion channel activity

1 reference

9 August 2016

acetylcholine-gated cation-selective channel activity

1 reference

9 August 2016

chloride channel regulator activity

1 reference

9 August 2016

protein homodimerization activity

1 reference

9 August 2016

acetylcholine binding

1 reference

9 August 2016

acetylcholine receptor activity

1 reference

9 August 2016

amyloid-beta binding

1 reference

9 August 2016

toxic substance binding

1 reference

9 August 2016

amyloid-beta binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

1 reference

14 February 2019

adenylate cyclase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

toxic substance binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

chloride channel regulator activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

acetylcholine-gated cation-selective channel activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Linkage of strain-specific nicotinic receptor alpha 7 subunit restriction fragment length polymorphisms with levels of alpha-bungarotoxin binding in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

14 February 2019

Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

ATPase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

scaffold protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

integral component of membrane

cell component

3 references

postsynaptic membrane

3 references

membrane

4 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

14 February 2019

A role for LYNX2 in anxiety-related behavior

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

synapse

1 reference

9 August 2016

cell junction

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

plasma membrane

acetylcholine-gated channel complex

3 references

1 reference

9 August 2016

cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

integral component of plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

postsynaptic density

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

axon

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

dendrite

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

growth cone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

asymmetric synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

presynaptic membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

neuron projection

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

soma

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

dendritic spine

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

dendritic shaft

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

plasma membrane raft

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

membrane raft

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

glycinergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

presynapse

TAS

1 reference

14 February 2019

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

integral component of spine apparatus membrane

TAS

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

biological process

associative learning

3 references

9 August 2016

14 February 2019

Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Impaired passive avoidance learning in mice lacking central neuronal nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

memory

1 reference

9 August 2016

B cell activation

transport

1 reference

9 August 2016

regulation of membrane potential

1 reference

9 August 2016

cation transmembrane transport

1 reference

9 August 2016

ion transport

5 references

9 August 2016

14 February 2019

Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

calcium ion transport

1 reference

9 August 2016

ion transmembrane transport

1 reference

9 August 2016

cognition

1 reference

9 August 2016

synaptic transmission, cholinergic

1 reference

9 August 2016

cellular calcium ion homeostasis

1 reference

9 August 2016

positive regulation of angiogenesis

1 reference

9 August 2016

positive regulation of cell population proliferation

1 reference

9 August 2016

signal transduction

1 reference

9 August 2016

response to hypoxia

1 reference

9 August 2016

negative regulation of tumor necrosis factor production

1 reference

9 August 2016

response to nicotine

1 reference

9 August 2016

response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

negative regulation of protein phosphorylation

1 reference

14 February 2019

Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of protein phosphorylation

1 reference

14 February 2019

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

calcium ion transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

cellular calcium ion homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

chemical synaptic transmission

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

synaptic transmission, cholinergic

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

learning or memory

3 references

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

response to cold

1 reference

14 February 2019

Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

neuronal action potential

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of synaptic transmission, cholinergic

1 reference

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

negative regulation of tumor necrosis factor production

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of peptidyl-serine phosphorylation

1 reference

14 February 2019

Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

ion transmembrane transport

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of membrane potential

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

modulation of chemical synaptic transmission

1 reference

14 February 2019

Mossy fiber long-term potentiation deficits in BACE1 knock-outs can be rescued by activation of alpha7 nicotinic acetylcholine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

synapse organization

1 reference

14 February 2019

Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

nervous system process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

cognition

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of synapse structural plasticity

1 reference

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of postsynaptic membrane potential

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

excitatory postsynaptic potential

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

negative regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of ERK1 and ERK2 cascade

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

acetylcholine receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

dendritic spine organization

1 reference

14 February 2019

Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

modulation of excitatory postsynaptic potential

dendrite arborization

1 reference

14 February 2019

Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of long-term synaptic potentiation

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Activation of nicotinic α7 acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

14 February 2019

Activation of nicotinic α7 acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of neuron death

1 reference

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of amyloid-beta formation

1 reference

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

negative regulation of amyloid-beta formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of amyloid precursor protein catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

response to amyloid-beta

1 reference

14 February 2019

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

response to acetylcholine

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of amyloid fibril formation

1 reference

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of CoA-transferase activity

1 reference

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of acetylcholine biosynthetic process

1 reference

14 February 2019

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

regulation of synaptic vesicle exocytosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

positive regulation of excitatory postsynaptic potential

1 reference

14 February 2019

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49582

Neurotransmitter-gated ion-channel, conserved site

has part(s)

1 reference

Neurotransmitter-gated ion-channel ligand-binding domain

1 reference

Neurotransmitter-gated ion-channel transmembrane domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

20 October 2015

1 reference

20 October 2015

1 reference

20 October 2015

1 reference

20 October 2015

1 reference

20 October 2015

1 reference

20 October 2015