Protein inhibitor of activated STAT 4 (Q21118240)

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mammalian protein found in Homo sapiens

zinc finger, MIZ-type containing 6
protein inhibitor of activated STAT protein gamma
PIAS4
RING-type E3 ubiquitin transferase PIAS4
protein inhibitor of activated STAT protein PIASy
protein inhibitor of activated STAT protein 4
E3 SUMO-protein ligase PIAS4
PIAS-gamma
PIASy

Language	Label	Description	Also known as
English	Protein inhibitor of activated STAT 4	mammalian protein found in Homo sapiens	zinc finger, MIZ-type containing 6 protein inhibitor of activated STAT protein gamma PIAS4 RING-type E3 ubiquitin transferase PIAS4 protein inhibitor of activated STAT protein PIASy protein inhibitor of activated STAT protein 4 E3 SUMO-protein ligase PIAS4 PIAS-gamma PIASy

Statements

1 reference

13 November 2019

UniProt protein ID

SAP domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N2W9

E3 SUMO-protein ligase PIAS4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N2W9

PINIT domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N2W9

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N2W9

Zinc finger, MIZ-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

PINIT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SAP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription corepressor activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

protein binding

determination method or standard

9 references

8 April 2019

Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

ubiquitin protein ligase binding

determination method or standard

2 references

8 April 2019

The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

SUMO transferase activity

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

protein C-terminus binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

determination method or standard

1 reference

8 April 2019

The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

transferase complex

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

determination method or standard

5 references

8 April 2019

Inhibition of Stat1-mediated gene activation by PIAS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

biological process

regulation of transcription, DNA-templated

determination method or standard

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N2W9&geneProductId=UniProtKB:Q8N2W9

determination method or standard

negative regulation of tumor necrosis factor-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

Wnt signaling pathway

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

positive regulation of protein sumoylation

determination method or standard

protein sumoylation

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

8 April 2019

Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N2W9&geneProductId=UniProtKB:Q8N2W9

determination method or standard

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

double-strand break repair via nonhomologous end joining

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

negative regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

vitamin D metabolic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N2W9

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N2W9

Zinc finger, MIZ-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N2W9

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N2W9

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000262971

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000262971

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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