TNF receptor superfamily member 10a (Q21116615)

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mammalian protein found in Homo sapiens

cytotoxic TRAIL receptor
TNF-related apoptosis-inducing ligand receptor 1
TRAIL-R1
tumor necrosis factor receptor superfamily member 10a variant 2
TRAIL receptor 1
tumor necrosis factor receptor superfamily, member 10a
death receptor 4
TNFRSF10A
tumor necrosis factor receptor superfamily member 10A

Language	Label	Description	Also known as
English	TNF receptor superfamily member 10a	mammalian protein found in Homo sapiens	cytotoxic TRAIL receptor TNF-related apoptosis-inducing ligand receptor 1 TRAIL-R1 tumor necrosis factor receptor superfamily member 10a variant 2 TRAIL receptor 1 tumor necrosis factor receptor superfamily, member 10a death receptor 4 TNFRSF10A tumor necrosis factor receptor superfamily member 10A

Statements

1 reference

13 November 2019

UniProt protein ID

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

Tumour necrosis factor receptor 10

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O00220

Tumor necrosis factor receptor 10, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor receptor 10A/B, death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TNFR/NGFR cysteine-rich region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transcription factor binding

determination method or standard

1 reference

1 January 2018

Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

protease binding

determination method or standard

1 reference

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

protein binding

determination method or standard

6 references

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

tumor necrosis factor-activated receptor activity

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

death receptor activity

determination method or standard

1 reference

1 January 2018

The receptor for the cytotoxic ligand TRAIL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

signaling receptor activity

determination method or standard

1 reference

1 January 2018

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

plasma membrane

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

determination method or standard

1 reference

5 June 2018

N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

integral component of membrane

determination method or standard

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

determination method or standard

biological process

activation of NF-kappaB-inducing kinase activity

determination method or standard

2 references

1 January 2018

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

1 January 2018

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

TRAIL-activated apoptotic signaling pathway

determination method or standard

1 reference

5 June 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

multicellular organism development

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

cell surface receptor signaling pathway

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

1 January 2018

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

regulation of cell population proliferation

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

immune response

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

inflammatory response

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

extrinsic apoptotic signaling pathway

determination method or standard

1 reference

1 January 2018

DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

tumor necrosis factor-mediated signaling pathway

determination method or standard

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

leukocyte migration

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00220&geneProductId=UniProtKB:O00220

determination method or standard

TRAIL-activated apoptotic signaling pathway

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00220

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000221132

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000221132

ENSP00000428884

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428884

ENSP00000480778

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480778

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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