DOT1 like histone lysine methyltransferase (Q21116404)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

histone methyltransferase DOT1L
histone-lysine N-methyltransferase, H3 lysine-79 specific
histone H3-K79 methyltransferase
DOT1L
DOT1 like histone H3K79 methyltransferase
DOT1-like protein
DOT1-like histone methyltransferase
DOT1-like, histone H3 methyltransferase
H3-K79-HMTase
lysine N-methyltransferase 4

Language	Label	Description	Also known as
English	DOT1 like histone lysine methyltransferase	mammalian protein found in Homo sapiens	histone methyltransferase DOT1L histone-lysine N-methyltransferase, H3 lysine-79 specific histone H3-K79 methyltransferase DOT1L DOT1 like histone H3K79 methyltransferase DOT1-like protein DOT1-like histone methyltransferase DOT1-like, histone H3 methyltransferase H3-K79-HMTase lysine N-methyltransferase 4

Statements

1 reference

13 November 2019

UniProt protein ID

Histone H3-K79 methyltransferase, metazoa

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TEK3

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TEK3

Histone-lysine N-methyltransferase DOT1 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

methyltransferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

transcription factor binding

determination method or standard

1 reference

21 June 2018

A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEK3&geneProductId=UniProtKB:Q8TEK3

determination method or standard

protein binding

determination method or standard

4 references

8 April 2019

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

histone-lysine N-methyltransferase activity

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

Modulation of p53 function by SET8-mediated methylation at lysine 382

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

histone methyltransferase activity (H3-K79 specific)

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEK3&geneProductId=UniProtKB:Q8TEK3

determination method or standard

determination method or standard

3 references

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEK3&geneProductId=UniProtKB:Q8TEK3

determination method or standard

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEK3&geneProductId=UniProtKB:Q8TEK3

determination method or standard

21 June 2018

hDOT1L links histone methylation to leukemogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEK3&geneProductId=UniProtKB:Q8TEK3

determination method or standard

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

intracellular membrane-bounded organelle

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

protein-containing complex

determination method or standard

1 reference

8 April 2019

hDOT1L links histone methylation to leukemogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

hDOT1L links histone methylation to leukemogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

biological process

telomere organization

determination method or standard

1 reference

8 April 2019

A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

regulation of transcription regulatory region DNA binding

determination method or standard

1 reference

21 June 2018

A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEK3&geneProductId=UniProtKB:Q8TEK3

determination method or standard

regulation of receptor signaling pathway via JAK-STAT

determination method or standard

1 reference

8 April 2019

A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

hDOT1L links histone methylation to leukemogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

positive regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

hDOT1L links histone methylation to leukemogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

DNA damage checkpoint signaling

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

determination method or standard

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEK3&geneProductId=UniProtKB:Q8TEK3

determination method or standard

chromatin organization

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

regulation of cell cycle

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEK3

determination method or standard

regulation of transcription regulatory region DNA binding

determination method or standard

Histone-lysine N-methyltransferase DOT1 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TEK3

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000381657

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381657

ENSP00000404284

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000404284

ENSP00000407411

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407411

ENSP00000412916

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412916

ENSP00000476469

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476469

ENSP00000484015

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484015

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21116404&oldid=2022966297"