Frizzled class receptor 4 (Q21115948)

protein homodimerization activity

1 reference

1 January 2018

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

signal transducer activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

1 reference

14 February 2017

protein binding

5 references

1 January 2018

Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

protein heterodimerization activity

1 reference

1 January 2018

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

Wnt-activated receptor activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

3 references

14 February 2017

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

ubiquitin protein ligase binding

1 reference

1 January 2018

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

transmembrane signaling receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

Wnt-protein binding

1 reference

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

amyloid-beta binding

1 reference

1 January 2018

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

Wnt-protein binding

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

Wnt-activated receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

5 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

protein-containing complex binding

1 reference

1 January 2018

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

clathrin-coated endocytic vesicle membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

cell-cell junction

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

plasma membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

6 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

integral component of plasma membrane

1 reference

1 January 2018

Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

cell surface

1 reference

1 January 2018

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

extracellular exosome

1 reference

14 February 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

clathrin-coated vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

synapse

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

glutamatergic synapse

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

negative regulation of cell-substrate adhesion

biological process

Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

cellular response to retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

G protein-coupled receptor signaling pathway

ISS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

luteinization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

extracellular matrix-cell signaling

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

positive regulation of JUN kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

hearing

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

4 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

14 February 2017

Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

vasculogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

positive regulation of transcription, DNA-templated

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

cerebellum vasculature morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

progesterone secretion

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

blood vessel development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

retinal blood vessel morphogenesis

ISS

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

canonical Wnt signaling pathway

3 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

substrate adhesion-dependent cell spreading

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

locomotion involved in locomotory behavior

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

retina vasculature morphogenesis in camera-type eye

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

3 references

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

IMP

14 February 2017

Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

14 February 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q9ULV1

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

Wnt signaling pathway, planar cell polarity pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

membrane organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 reference

1 January 2018

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Moderate reduction of Norrin signaling activity associated with the causative missense mutations identified in patients with familial exudative vitreoretinopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

non-canonical Wnt signaling pathway

canonical Wnt signaling pathway

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

retina vasculature morphogenesis in camera-type eye

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

IMP

1 January 2018

Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

cellular response to leukemia inhibitory factor

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9ULV1

http://purl.uniprot.org/uniprot/Q9ULV1

exact match

1 reference

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ULV1

GPCR, family 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ULV1

Frizzled/Smoothened, transmembrane domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ULV1

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016