Apolipoprotein B mRNA editing enzyme catalytic subunit 3A (Q21115213)

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mammalian protein found in Homo sapiens

• apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
• APOBEC3A
• phorbolin-1
• probable DNA dC->dU-editing enzyme APOBEC-3A
• APOBEC3A_B
• DNA dC->dU-editing enzyme APOBEC-3A

edit

Language	Label	Description	Also known as
English	Apolipoprotein B mRNA editing enzyme catalytic subunit 3A	mammalian protein found in Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A APOBEC3A phorbolin-1 probable DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A_B DNA dC->dU-editing enzyme APOBEC-3A

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31941

part of

Cytidine deaminase-like

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31941

Cytidine and deoxycytidylate deaminase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

APOBEC/CMP deaminase, zinc-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31941

encoded by

APOBEC3A_B

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31941

APOBEC3A

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31941

molecular function

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

determination method or standard

IEA

1 reference

retrieved

10 September 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IEA

cytidine deaminase activity

determination method or standard

IDA

IMP

3 references

retrieved

24 April 2018

stated in

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IMP

retrieved

24 April 2018

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

24 April 2018

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

zinc ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

hydrolase activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

protein binding

determination method or standard

IPI

2 references

retrieved

8 April 2019

stated in

HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IPI

retrieved

8 April 2019

stated in

Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IPI

catalytic activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

metal ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

deoxycytidine deaminase activity

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IMP

RNA binding

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IBA

cytidine deaminase activity

determination method or standard

IBA

IDA

IMP

4 references

retrieved

8 April 2019

stated in

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IMP

retrieved

8 April 2019

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IBA

cell component

cytoplasm

determination method or standard

IDA

IEA

4 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IEA

retrieved

24 April 2018

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

24 April 2018

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

24 April 2018

stated in

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

nucleus

determination method or standard

IDA

IEA

5 references

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IEA

retrieved

24 April 2018

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

24 April 2018

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

24 April 2018

stated in

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

24 April 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

nucleus

determination method or standard

IBA

IDA

IEA

6 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

retrieved

8 April 2019

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IBA

cytoplasm

determination method or standard

IBA

IDA

IEA

5 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

retrieved

8 April 2019

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IBA

biological process

cellular response to xenobiotic stimulus

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

negative regulation of transposition

determination method or standard

IDA

3 references

retrieved

8 April 2019

stated in

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

DNA demethylation

determination method or standard

IDA

1 reference

retrieved

24 April 2018

stated in

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P31941&geneProductId=UniProtKB:P31941

determination method or standard

IDA

negative regulation of viral genome replication

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

innate immune response

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

retrieved

8 April 2019

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

defense response to virus

determination method or standard

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

retrieved

8 April 2019

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

DNA cytosine deamination

determination method or standard

IDA

IMP

3 references

retrieved

8 April 2019

stated in

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IMP

retrieved

8 April 2019

stated in

APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

immune system process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

cytidine deamination

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IEA

cytidine to uridine editing

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IBA

DNA demethylation

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

GOA

curator

UniProt

UniProt protein ID

P31941

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31941

determination method or standard

IBA

has part(s)

Cytidine and deoxycytidylate deaminase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31941

APOBEC/CMP deaminase, zinc-binding

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P31941

Identifiers

RefSeq protein ID

NP_001257335

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

200315

NP_663745

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

200315

UniProt protein ID

P31941

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P31941

Ensembl protein ID

ENSP00000249116

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000249116

ENSP00000384359

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000384359

ENSP00000461288

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000461288

ENSP00000481904

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000481904

ENSP00000485234

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000485234

PDB structure ID

2M65

1 reference

stated in

UniProt

UniProt protein ID

P31941

retrieved

9 August 2016

language of work or name

English

4XXO

1 reference

stated in

UniProt

UniProt protein ID

P31941

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

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Wikibooks(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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