ATP binding cassette subfamily A member 1 (Q21115210)

ABC transporter A

1 reference

ATP-binding cassette transporter

1 reference

Transporter Classification Database ID

3.A.1.211.14

2 October 2019

hierarchical database ID heuristic

AAA proteins

1 reference

inferred from protein domain or family

ABC transporter-like, protein family

1 reference

inferred from protein domain or family

ABC transporter, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

ATPase-coupled transmembrane transporter activity

3 references

apolipoprotein binding

1 reference

9 May 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

1 reference

9 May 2019

ATPase binding

1 reference

9 May 2019

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

apolipoprotein A-I receptor activity

1 reference

9 May 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cholesterol binding

1 reference

9 May 2019

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

small GTPase binding

1 reference

9 May 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

protein binding

9 references

9 May 2019

Molecular interactions between apoE and ABCA1: impact on apoE lipidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

syntaxin binding

1 reference

9 May 2019

Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

signaling receptor binding

1 reference

9 May 2019

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

phospholipid binding

1 reference

9 May 2019

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

9 May 2019

Characterization of the ATPase cycle of human ABCA1: implications for its function as a regulator rather than an active transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

phosphatidylserine floppase activity

1 reference

10 September 2018

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477

phosphatidylcholine floppase activity

1 reference

10 September 2018

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477

high-density lipoprotein particle binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

lipid transporter activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cholesterol transfer activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

phosphatidylcholine floppase activity

phosphatidylserine floppase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

1 reference

9 May 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

4 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

endocytic vesicle

1 reference

9 May 2019

The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cell surface

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

phagocytic vesicle

1 reference

9 May 2019

Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

high-density lipoprotein particle

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477

perinuclear region of cytoplasm

1 reference

9 May 2019

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

membrane raft

1 reference

9 May 2019

Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

external side of plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

1 reference

9 May 2019

endosome

1 reference

9 May 2019

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

G protein-coupled receptor signaling pathway

biological process

1 reference

9 May 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cellular response to retinoic acid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

phospholipid homeostasis

1 reference

9 May 2019

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

1 reference

9 May 2019

platelet dense granule organization

1 reference

9 May 2019

Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

regulation of Cdc42 protein signal transduction

1 reference

9 May 2019

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

response to nutrient

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

1 reference

9 May 2019

phospholipid efflux

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477

10 September 2018

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477

10 September 2018

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95477&geneProductId=UniProtKB:O95477

phospholipid transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cholesterol transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

response to laminar fluid shear stress

1 reference

9 May 2019

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

peptide secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cholesterol metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cellular response to cholesterol

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

negative regulation of cholesterol storage

1 reference

9 May 2019

Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

endosomal transport

1 reference

9 May 2019

The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

phagocytosis, engulfment

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

anion transmembrane transport

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

intracellular cholesterol transport

1 reference

9 May 2019

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cholesterol efflux

Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

protein lipidation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

lipoprotein biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

lysosome organization

1 reference

9 May 2019

Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cellular response to lipopolysaccharide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

negative regulation of macrophage derived foam cell differentiation

1 reference

9 May 2019

Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

apolipoprotein A-I-mediated signaling pathway

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

regulation of high-density lipoprotein particle assembly

1 reference

9 May 2019

Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

1 reference

9 May 2019

cholesterol homeostasis

regulation of lipid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

1 reference

9 May 2019

high-density lipoprotein particle assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

4 references

9 May 2019

9 May 2019

Molecular interactions between apoE and ABCA1: impact on apoE lipidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

lipoprotein metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

9 May 2019

Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

cellular response to low-density lipoprotein particle stimulus

1 reference

9 May 2019

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

lipid transport

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

phospholipid efflux

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95477

physically interacts with

2 references

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7277

language of work or name

English

17 August 2016

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL608

probucol

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL608

Gene Atlas image

PBB GE ABCA1 216066 at fs.png
732 × 530; 12 KB

0 references

PBB GE ABCA1 203504 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

ABC transporter, conserved site

1 reference

ABC transporter-like

1 reference

AAA+ ATPase domain

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Transporter Classification Database ID

3.A.1.211.14

2 references

Transporter Classification database

13 March 2020

Transporter Classification database