ATPase cation transporting 13A2 (Q21115193)

HAD-like superfamily

1 reference

P-type ATPase, transmembrane domain superfamily

1 reference

P-type ATPase, subfamily V

1 reference

P-type ATPase, cytoplasmic domain N

1 reference

HAD superfamily

1 reference

Transporter Classification Database ID

P-type ATPase

1 reference

3.A.3.10.7

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

protein binding

IPI

1 reference

8 April 2019

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

IPI

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

cupric ion binding

ISS

1 reference

8 April 2019

Interaction of divalent cations with peptide fragments from Parkinson's disease genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

phosphatidic acid binding

ISS

1 reference

8 April 2019

A lipid switch unlocks Parkinson's disease-associated ATP13A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

phosphatidylinositol-3,5-bisphosphate binding

1 reference

8 April 2019

A lipid switch unlocks Parkinson's disease-associated ATP13A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

P-type calcium transporter activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

1 reference

26 September 2017

ATPase-coupled cation transmembrane transporter activity

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

integral component of membrane

cell component

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

1 reference

26 September 2017

IBA

transport vesicle

1 reference

8 April 2019

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

lysosomal lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

lysosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

5 references

8 April 2019

8 April 2019

Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

vesicle

1 reference

8 April 2019

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

multivesicular body

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

integral component of lysosomal membrane

1 reference

8 April 2019

A lipid switch unlocks Parkinson's disease-associated ATP13A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

multivesicular body membrane

1 reference

8 April 2019

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

autophagosome

1 reference

8 April 2019

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

late endosome

1 reference

8 April 2019

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

lysosomal membrane

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

26 September 2017

26 September 2017

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

26 September 2017

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

lysosomal membrane

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

8 April 2019

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cellular cation homeostasis

HDA

biological process

1 reference

8 April 2019

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cation transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

ion transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

1 reference

8 April 2019

regulation of autophagy of mitochondrion

1 reference

8 April 2019

ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

regulation of autophagosome size

1 reference

26 September 2017

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

regulation of endopeptidase activity

1 reference

8 April 2019

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

regulation of mitochondrion organization

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cellular response to oxidative stress

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

A lipid switch unlocks Parkinson's disease-associated ATP13A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cellular calcium ion homeostasis

1 reference

8 April 2019

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cellular response to manganese ion

Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cellular iron ion homeostasis

1 reference

8 April 2019

Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

protein autophosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cellular zinc ion homeostasis

1 reference

8 April 2019

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

autophagosome organization

1 reference

8 April 2019

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

regulation of glucosylceramidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

regulation of chaperone-mediated autophagy

1 reference

8 April 2019

Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

negative regulation of neuron death

regulation of intracellular protein transport

ISS

2 references

1 reference

8 April 2019

Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

positive regulation of protein secretion

1 reference

8 April 2019

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

positive regulation of exosomal secretion

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

peptidyl-aspartic acid autophosphorylation

1 reference

8 April 2019

A lipid switch unlocks Parkinson's disease-associated ATP13A2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

negative regulation of lysosomal protein catabolic process

1 reference

8 April 2019

Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

cellular response to zinc ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

calcium ion transmembrane transport

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQ11&geneProductId=UniProtKB:Q9NQ11

regulation of lysosomal protein catabolic process

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

extracellular exosome biogenesis

1 reference

8 April 2019

ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

polyamine transmembrane transport

1 reference

8 April 2019

Parkinson's disease-associated human P5B-ATPase ATP13A2 increases spermidine uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQ11

P-type ATPase, phosphorylation site

has part(s)

1 reference

Transporter Classification Database ID

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

3.A.3.10.7

2 references

Transporter Classification database

13 March 2020

Transporter Classification database