RAB27A, member RAS oncogene family (Q21114928)

http://www.ebi.ac.uk/interpro/protein/P51159

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51159

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

GDP binding

1 reference

8 April 2019

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

GTP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

myosin V binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

protein binding

7 references

8 April 2019

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

In vitro reconstitution of a transport complex containing Rab27a, melanophilin and myosin Va

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

GTPase activity

ISS

GTPase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

cell component

Weibel-Palade body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

Golgi apparatus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

multivesicular body membrane

1 reference

8 April 2019

Rab27a and Rab27b control different steps of the exosome secretion pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

exocytic vesicle

secretory granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

melanosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51159&geneProductId=UniProtKB:P51159

3 references

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51159&geneProductId=UniProtKB:P51159

31 October 2017

Rab27a: A key to melanosome transport in human melanocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51159&geneProductId=UniProtKB:P51159

photoreceptor outer segment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

dendrite

1 reference

8 April 2019

Rab27a: A key to melanosome transport in human melanocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

extracellular exosome

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

melanosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

specific granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

synapse

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

melanosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Rab27a: A key to melanosome transport in human melanocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

positive regulation of reactive oxygen species biosynthetic process

biological process

1 reference

8 April 2019

Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

natural killer cell degranulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

protein targeting

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

positive regulation of phagocytosis

1 reference

8 April 2019

Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

antigen processing and presentation

1 reference

8 April 2019

The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

multivesicular body sorting pathway

1 reference

8 April 2019

Rab27a and Rab27b control different steps of the exosome secretion pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

pigment granule localization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

blood coagulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

pigment granule transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

positive regulation of gene expression

1 reference

8 April 2019

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

multivesicular body organization

1 reference

8 April 2019

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

positive regulation of constitutive secretory pathway

1 reference

8 April 2019

A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

synaptic vesicle transport

1 reference

8 April 2019

Synaptic vesicle trafficking and Parkinson's disease

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

complement-dependent cytotoxicity

1 reference

8 April 2019

Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

pigmentation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

cytotoxic T cell degranulation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

exosomal secretion

1 reference

8 April 2019

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

positive regulation of exocytosis

1 reference

31 October 2017

Rab27a and Rab27b control different steps of the exosome secretion pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51159&geneProductId=UniProtKB:P51159

melanocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

vesicle-mediated transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

positive regulation of regulated secretory pathway

IGI

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

1 reference

8 April 2019

intracellular protein transport

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

melanosome transport

A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

Rab protein signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51159

small GTP-binding protein domain

has part(s)

1 reference

InterPro Release 71.0