Receptor interacting serine/threonine kinase 1 (Q21101871)

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mammalian protein found in Homo sapiens
  • serine/threonine-protein kinase RIP
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • RIPK1
  • receptor-interacting protein 1
  • cell death protein RIP
  • RIP-1
  • receptor-interacting protein kinase 1
  • receptor-interacting serine/threonine-protein kinase 1
edit
Language Label Description Also known as
English
Receptor interacting serine/threonine kinase 1
mammalian protein found in Homo sapiens
  • serine/threonine-protein kinase RIP
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • RIPK1
  • receptor-interacting protein 1
  • cell death protein RIP
  • RIP-1
  • receptor-interacting protein kinase 1
  • receptor-interacting serine/threonine-protein kinase 1

Statements

molecular function
protein binding
determination method or standard
IPI
41 references
retrieved
8 April 2019
stated in
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
WDFY1 mediates TLR3/4 signaling by recruiting TRIF
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
SH3RF2 functions as an oncogene by mediating PAK4 protein stability
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
TNF-alpha induces two distinct caspase-8 activation pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Casein kinase 1alpha interacts with RIP1 and regulates NF-kappaB activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
In silico prediction of physical protein interactions and characterization of interactome orphans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
A type III effector antagonizes death receptor signalling during bacterial gut infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ubiquitin-specific protease 4 promotes TNF-α-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
retrieved
8 April 2019
stated in
Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IPI
cell component
biological process
necroptosis
determination method or standard
IEA
IMP
ISS
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
ISS
retrieved
8 April 2019
stated in
The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IMP
retrieved
8 April 2019
stated in
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IMP
retrieved
8 April 2019
stated in
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
GOA
curator
UniProt
UniProt protein ID
Q13546
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13546
determination method or standard
IEA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21101871&oldid=2022917538"