5-hydroxytryptamine receptor 4 (Q21109365)

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mammalian protein found in Homo sapiens

5-hydroxytryptamine receptor 4 transcript variant b2
Serotonin receptor 4
HTR4
cardiac 5-HT4 receptor
5-hydroxytryptamine receptor 4 transcript variant b3
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin 4 receptor

Language	Label	Description	Also known as
English	5-hydroxytryptamine receptor 4	mammalian protein found in Homo sapiens	5-hydroxytryptamine receptor 4 transcript variant b2 Serotonin receptor 4 HTR4 cardiac 5-HT4 receptor 5-hydroxytryptamine receptor 4 transcript variant b3 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin 4 receptor

Statements

1 reference

13 November 2019

UniProt protein ID

5-Hydroxytryptamine 4 receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13639

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

signal transducer activity

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

G protein-coupled serotonin receptor activity

determination method or standard

3 references

5 June 2018

Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

5 June 2018

A high-affinity monoclonal antibody with functional activity against the 5-hydroxytryptaminergic (5-HT4) receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

trace-amine receptor activity

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

identical protein binding

determination method or standard

1 reference

5 June 2018

Constitutive dimerization of human serotonin 5-HT4 receptors in living cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

G protein-coupled receptor activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

G protein-coupled serotonin receptor activity

determination method or standard

4 references

8 April 2019

Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

A high-affinity monoclonal antibody with functional activity against the 5-hydroxytryptaminergic (5-HT4) receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

neurotransmitter receptor activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

determination method or standard

1 reference

8 April 2019

Expression of serotonin receptors 2B and 4 in human prostate cancer tissue and effects of their antagonists on prostate cancer cell lines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

integral component of plasma membrane

determination method or standard

3 references

8 April 2019

Molecular and functional characterization of a 5-HT4 receptor cloned from human atrium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

biological process

gamma-aminobutyric acid signaling pathway

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

determination method or standard

1 reference

5 June 2018

Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

regulation of appetite

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

chemical synaptic transmission

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13639&geneProductId=UniProtKB:Q13639

determination method or standard

G protein-coupled serotonin receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13639

determination method or standard

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

determination method or standard

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

5-methoxytryptamine

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL267044

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL37744

object of statement has role

Partial agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2027925

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3544975

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2402904

metoclopramide hydrochloride hydrate

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200940

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13639

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353915

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353915

ENSP00000355037

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355037

ENSP00000367120

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367120

ENSP00000427913

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427913

ENSP00000428320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428320

ENSP00000430874

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430874

ENSP00000430979

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430979

ENSP00000435904

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435904

ENSP00000485747

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485747

ENSP00000429634

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429634

ENSP00000430451

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430451

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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