Solute carrier family 8 member B1 (Q21109032)

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mammalian protein found in Homo sapiens

• sodium/calcium exchanger protein, mitochondrial
• solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
• solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
• solute carrier family 24 member 6
• Na(+)/K(+)/Ca(2+)-exchange protein 6
• mitochondrial sodium/calcium exchanger protein
• solute carrier family 24 (sodium/lithium/calcium exchanger), member 6
• sodium/potassium/calcium exchanger 6, mitochondrial
• SLC8B1

edit

Language	Label	Description	Also known as
English	Solute carrier family 8 member B1	mammalian protein found in Homo sapiens	sodium/calcium exchanger protein, mitochondrial solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 solute carrier family 24 member 6 Na(+)/K(+)/Ca(2+)-exchange protein 6 mitochondrial sodium/calcium exchanger protein solute carrier family 24 (sodium/lithium/calcium exchanger), member 6 sodium/potassium/calcium exchanger 6, mitochondrial SLC8B1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q6J4K2

part of

potassium-dependent sodium-calcium exchanger

1 reference

Transporter Classification Database ID

2.A.19.4.4

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

Sodium/calcium exchanger membrane region, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q6J4K2

encoded by

SLC8B1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q6J4K2

molecular function

protein homodimerization activity

determination method or standard

IEA

IPI

2 references

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IPI

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

identical protein binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

antiporter activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

calcium:cation antiporter activity

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

calcium:sodium antiporter activity

determination method or standard

IDA

IEA

IMP

TAS

6 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

retrieved

8 April 2019

stated in

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

retrieved

8 April 2019

stated in

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential

determination method or standard

IEA

ISS

TAS

3 references

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

cell component

integral component of membrane

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

plasma membrane

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

mitochondrial crista

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

mitochondrion

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

integral component of mitochondrial membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

sarcolemma

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

mitochondrial inner membrane

determination method or standard

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

biological process

sodium ion transmembrane transport

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

regulation of cytosolic calcium ion concentration

determination method or standard

IEA

IMP

2 references

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

glucose homeostasis

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

response to stimulus

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

regulation of insulin secretion

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

sodium ion transport

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

ion transport

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

calcium ion transmembrane transport

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

regulation of cardiac muscle cell membrane potential

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

calcium ion transport

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

transmembrane transport

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

mitochondrial calcium ion transmembrane transport

determination method or standard

IDA

IEA

IMP

TAS

5 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

TAS

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

retrieved

8 April 2019

stated in

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

mitochondrial calcium ion homeostasis

determination method or standard

IDA

IEA

IMP

3 references

retrieved

8 April 2019

stated in

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

calcium export from the mitochondrion

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

retrieved

8 April 2019

stated in

NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

regulation of lymphocyte chemotaxis

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IEA

regulation of store-operated calcium entry

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

GOA

curator

UniProt

UniProt protein ID

Q6J4K2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6J4K2

determination method or standard

IDA

has part(s)

Sodium/calcium exchanger membrane region

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q6J4K2

Identifiers

RefSeq protein ID

NP_001317395

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

80024

NP_079235

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

80024

XP_011537054

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

80024

XP_016875467

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

80024

NP_001345274

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

80024

UniProt protein ID

Q6J4K2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q6J4K2

Ensembl protein ID

ENSP00000202831

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000202831

ENSP00000447091

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000447091

ENSP00000450081

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000450081

ENSP00000447502

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000447502

ENSP00000447585

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000447585

ENSP00000447972

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000447972

ENSP00000448703

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000448703

ENSP00000448749

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000448749

ENSP00000448758

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000448758

ENSP00000449448

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000449448

ENSP00000449519

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000449519

Transporter Classification Database ID

2.A.19.4.4

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

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Wikisource(0 entries)

edit

Wikiversity(0 entries)

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Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21109032&oldid=2022935935"