Lysine methyltransferase 5A (Q21107587)

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mammalian protein found in Homo sapiens

• PR-Set7
• PR/SET domain containing protein 8
• H4-K20-HMTase KMT5A
• H4-K20-specific histone methyltransferase
• lysine (K)-specific methyltransferase 5A
• lysine N-methyltransferase 5A
• KMT5A
• N-lysine methyltransferase KMT5A
• PR/SET domain-containing protein 07
• 2.1.1.43
• SET domain-containing protein 8
• PR/SET07
• histone-lysine N-methyltransferase SETD8
• N-lysine methyltransferase SETD8
• lysine-specific methylase 5A
• SET domain containing (lysine methyltransferase) 8
• H4K20-specific histone methyltransferase splice variant Set8b
• H4-K20-HMTase SETD8
• histone-lysine N-methyltransferase KMT5A

edit

Language	Label	Description	Also known as
English	Lysine methyltransferase 5A	mammalian protein found in Homo sapiens	PR-Set7 PR/SET domain containing protein 8 H4-K20-HMTase KMT5A H4-K20-specific histone methyltransferase lysine (K)-specific methyltransferase 5A lysine N-methyltransferase 5A KMT5A N-lysine methyltransferase KMT5A PR/SET domain-containing protein 07 2.1.1.43 SET domain-containing protein 8 PR/SET07 histone-lysine N-methyltransferase SETD8 N-lysine methyltransferase SETD8 lysine-specific methylase 5A SET domain containing (lysine methyltransferase) 8 H4K20-specific histone methyltransferase splice variant Set8b H4-K20-HMTase SETD8 histone-lysine N-methyltransferase KMT5A

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NQR1

part of

Class V SAM-dependent methyltransferases

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9NQR1

SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NQR1

encoded by

KMT5A

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NQR1

molecular function

protein-lysine N-methyltransferase activity

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Modulation of p53 function by SET8-mediated methylation at lysine 382

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IDA

methyltransferase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

transcription corepressor activity

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IDA

p53 binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Modulation of p53 function by SET8-mediated methylation at lysine 382

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IPI

protein binding

determination method or standard

IPI

3 references

retrieved

8 April 2019

stated in

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IPI

retrieved

8 April 2019

stated in

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IPI

retrieved

8 April 2019

stated in

Specificity and mechanism of the histone methyltransferase Pr-Set7.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IPI

transferase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

lysine N-methyltransferase activity

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

TAS

histone-lysine N-methyltransferase activity

determination method or standard

IEA

IDA

TAS

4 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

retrieved

8 April 2019

stated in

Modulation of p53 function by SET8-mediated methylation at lysine 382

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IDA

histone methyltransferase activity (H4-K20 specific)

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

TAS

cell component

nucleus

determination method or standard

IEA

IDA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IDA

nucleoplasm

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

TAS

chromosome

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

cytosol

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IDA

biological process

methylation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

regulation of transcription, DNA-templated

determination method or standard

IEA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQR1&geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

peptidyl-lysine monomethylation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Modulation of p53 function by SET8-mediated methylation at lysine 382

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IDA

cell cycle

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

negative regulation of transcription by RNA polymerase II

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Modulation of p53 function by SET8-mediated methylation at lysine 382

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IMP

negative regulation of transcription, DNA-templated

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IDA

cell division

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

transcription, DNA-templated

determination method or standard

IEA

1 reference

retrieved

27 February 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQR1&geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

regulation of DNA damage response, signal transduction by p53 class mediator

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Modulation of p53 function by SET8-mediated methylation at lysine 382

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IMP

histone lysine methylation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

regulation of signal transduction by p53 class mediator

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

TAS

histone H4-K20 methylation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

chromatin organization

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NQR1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQR1

determination method or standard

IEA

EC enzyme number

2.1.1.43

reason for deprecated rank

deprecated identifier value

1 reference

stated in

ENZYME

retrieved

22 April 2020

2.1.1.354

1 reference

stated in

ENZYME

retrieved

22 April 2020

exact match

https://identifiers.org/uniprot:Q9NQR1

1 reference

stated in

Identifiers.org

UniProt protein ID

Q9NQR1

reference URL

https://registry.identifiers.org/registry/uniprot

http://purl.uniprot.org/uniprot/Q9NQR1

1 reference

stated in

Identifiers.org

UniProt protein ID

Q9NQR1

reference URL

https://registry.identifiers.org/registry/uniprot

https://www.ncbi.nlm.nih.gov/protein/Q9NQR1

1 reference

stated in

Identifiers.org

UniProt protein ID

Q9NQR1

reference URL

https://registry.identifiers.org/registry/uniprot

has part(s)

SET domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9NQR1

Identifiers

RefSeq protein ID

NP_001311433

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

387893

NP_001311434

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

387893

NP_001311435

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

387893

NP_065115

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

387893

NP_001354315

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

387893

NP_001354317

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

387893

NP_001354318

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

387893

UniProt protein ID

Q9NQR1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NQR1

Ensembl protein ID

ENSP00000384629

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000384629

ENSP00000332995

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000332995

ENSP00000406830

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000406830

ENSP00000413811

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000413811

PDB structure ID

1ZKK

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

2BQZ

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

3F9W

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

3F9X

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

3F9Y

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

3F9Z

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

4IJ8

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

5HQ2

1 reference

stated in

UniProt

UniProt protein ID

Q9NQR1

retrieved

4 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21107587&oldid=2022930805"