BMX non-receptor tyrosine kinase (Q21106693)

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mammalian protein found in Homo sapiens

• ETK
• bone marrow tyrosine kinase gene in chromosome X protein
• NTK38
• epithelial and endothelial tyrosine kinase
• Etk/Bmx cytosolic tyrosine kinase
• NTK38 tyrosine kinase
• cytoplasmic tyrosine-protein kinase BMX
• BMX
• BTK-like on X chromosome

edit

Language	Label	Description	Also known as
English	BMX non-receptor tyrosine kinase	mammalian protein found in Homo sapiens	ETK bone marrow tyrosine kinase gene in chromosome X protein NTK38 epithelial and endothelial tyrosine kinase Etk/Bmx cytosolic tyrosine kinase NTK38 tyrosine kinase cytoplasmic tyrosine-protein kinase BMX BMX BTK-like on X chromosome

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51813

part of

Cytoplasmic tyrosine-protein kinase BMX

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

PH-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

SH2 domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

BMX, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, Btk motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51813

encoded by

BMX

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51813

molecular function

transferase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

nucleotide binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

protein kinase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

signal transducer activity

determination method or standard

TAS

1 reference

retrieved

24 April 2018

stated in

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

TAS

metal ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

kinase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

protein binding

determination method or standard

IPI

5 references

retrieved

8 April 2019

stated in

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IPI

retrieved

8 April 2019

stated in

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IPI

retrieved

8 April 2019

stated in

The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IPI

retrieved

8 April 2019

stated in

Phospho-tyrosine dependent protein-protein interaction network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IPI

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IPI

protein tyrosine kinase activity

determination method or standard

TAS

IEA

3 references

retrieved

8 April 2019

stated in

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

signaling receptor binding

determination method or standard

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IBA

ATP binding

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

non-membrane spanning protein tyrosine kinase activity

determination method or standard

IDA

IEA

TAS

5 references

retrieved

24 April 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

TAS

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IEA

retrieved

24 April 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IEA

retrieved

24 April 2018

stated in

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IDA

retrieved

24 April 2018

stated in

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IDA

non-membrane spanning protein tyrosine kinase activity

determination method or standard

IBA

IDA

IEA

TAS

6 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

retrieved

8 April 2019

stated in

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

retrieved

8 April 2019

stated in

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IBA

cell component

cytoplasm

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

cytosol

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

TAS

extrinsic component of cytoplasmic side of plasma membrane

determination method or standard

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IBA

ruffle membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

nucleoplasm

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

plasma membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

biological process

intracellular signal transduction

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

phosphorylation

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

NK T cell differentiation

determination method or standard

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IBA

transmembrane receptor protein tyrosine kinase signaling pathway

determination method or standard

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IBA

protein phosphorylation

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

cell adhesion

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

regulation of cell population proliferation

determination method or standard

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IBA

peptidyl-tyrosine autophosphorylation

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IBA

protein autophosphorylation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

mesoderm development

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

TAS

innate immune response

determination method or standard

IBA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51813&geneProductId=UniProtKB:P51813

determination method or standard

IBA

signal transduction

determination method or standard

IDA

2 references

retrieved

8 April 2019

stated in

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

retrieved

8 April 2019

stated in

Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IDA

apoptotic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P51813

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IEA

phosphatidylinositol biosynthetic process

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

TAS

adaptive immune response

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IBA

B cell receptor signaling pathway

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51813

determination method or standard

IBA

physically interacts with

ibrutinib

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6912

language of work or name

English

retrieved

17 August 2016

has part(s)

tyrosine-protein kinase, active site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

pleckstrin homology domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

protein kinase, ATP binding site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

protein kinase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

tyrosine-protein kinase, catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

SH2 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

Zinc finger, Btk motif

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

BMX, SH2 domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P51813

Identifiers

RefSeq protein ID

NP_001307795

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

660

NP_001712

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

660

NP_975010

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

660

XP_016885241

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

660

UniProt protein ID

P51813

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P51813

Ensembl protein ID

ENSP00000308774

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000308774

ENSP00000340082

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000340082

ENSP00000350224

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000350224

PDB structure ID

2EKX

1 reference

stated in

UniProt

UniProt protein ID

P51813

retrieved

4 August 2016

language of work or name

English

2YS2

1 reference

stated in

UniProt

UniProt protein ID

P51813

retrieved

4 August 2016

language of work or name

English

3SXR

1 reference

stated in

UniProt

UniProt protein ID

P51813

retrieved

4 August 2016

language of work or name

English

3SXS

1 reference

stated in

UniProt

UniProt protein ID

P51813

retrieved

4 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21106693&oldid=2022928747"