Artemisinin-resistant malaria: research challenges, opportunities, and public health implications (Q21032532)

artemisinins

1 reference

Plasmodium falciparum malaria

1 reference

28 May 2020

Plasmodium falciparum

2 references

22 October 2019

18 July 2021

2 references

18 July 2021

Rick M Fairhurst

Rick M

Fairhurst

1 reference

27 July 2022

Christopher V Plowe

Christopher V

Plowe

1 reference

27 July 2022

Pascal Ringwald

Pascal

Ringwald

1 reference

27 July 2022

Arjen M Dondorp

Arjen M

Dondorp

1 reference

27 July 2022

Joel G Breman

Joel G

Breman

1 reference

27 July 2022

Gaurvika M L Nayyar

Gaurvika M L

Nayyar

1 reference

27 July 2022

Rachel Hallett

Rachel

Hallett

1 reference

27 July 2022

Jonathan L Vennerstrom

Jonathan L

Vennerstrom

1 reference

27 July 2022

Socheat Duong

Socheat

Duong

1 reference

27 July 2022

Thomas E Wellems

Thomas E

Wellems

1 reference

American Journal of Tropical Medicine and Hygiene

27 July 2022

language of work or name

English

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publication date

August 2012

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1 August 2012

9 references

23 March 2019

22 June 2019

30 June 2019

22 October 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

14 January 2024

9 references

23 March 2019

22 June 2019

30 June 2019

22 October 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

14 January 2024

0 references

0 references

231-41

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Creative Commons Attribution 2.5 Generic

9 references

23 March 2019

22 June 2019

30 June 2019

22 October 2019

4 November 2019

7 November 2019

28 May 2020

18 July 2021

on focus list of Wikimedia project

14 January 2024

ScienceSource

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Qinghaosu (Artemisinin): The Price of Success

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Artemisinins target the SERCA of Plasmodium falciparum

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Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

19 March 2017

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Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance

19 March 2017

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Artesunate Dose Escalation for the Treatment of Uncomplicated Malaria in a Region of Reported Artemisinin Resistance: A Randomized Clinical Trial

19 March 2017

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Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum

19 March 2017

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The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

19 March 2017

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19 March 2017

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Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa.

7 April 2017

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Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

12 September 2017

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Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations

12 September 2017

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The parasite clearance curve

29 November 2018

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Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

12 September 2017

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Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

12 September 2017

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Artemisinin activity againstPlasmodium falciparumrequires hemoglobin uptake and digestion

12 September 2017

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Artesunate tolerance in transgenic Plasmodium falciparum parasites overexpressing a tryptophan-rich protein

12 September 2017

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Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure

12 September 2017

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Intrahost modeling of artemisinin resistance in Plasmodium falciparum

12 September 2017

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Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure

12 September 2017

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Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum

12 September 2017

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Application of mobile-technology for disease and treatment monitoring of malaria in the "Better Border Healthcare Programme"

12 September 2017

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Exploring the contribution of candidate genes to artemisinin resistance in Plasmodium falciparum

12 September 2017

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High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western Cambodia

12 September 2017

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Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation

12 September 2017

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Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine

12 September 2017

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Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism

12 September 2017

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In vivo parasitological measures of artemisinin susceptibility

12 September 2017

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The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia

12 September 2017

1 reference

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In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa

12 September 2017

1 reference

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Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1(19))

12 September 2017

1 reference

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World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria

12 September 2017

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Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites

12 September 2017

1 reference

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Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

12 September 2017

1 reference

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Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.

12 September 2017

1 reference

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Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?

12 September 2017

1 reference

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A medicinal chemistry perspective on artemisinin and related endoperoxides

12 September 2017

1 reference

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Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.

12 September 2017

1 reference

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Artemisinin: mechanisms of action, resistance and toxicity

12 September 2017

1 reference

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Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

12 September 2017

1 reference

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Central role of the spleen in malaria parasite clearance

12 September 2017

1 reference

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The public health impact of chloroquine resistance in Africa

12 September 2017

1 reference

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Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin We are grateful to the CNRS for financial support, and to the French Ministery of Education for a PhD grant to J.C. Dr. Yannick Coppel (LCC-CNRS) is gratefully a

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

A molecular marker for chloroquine-resistant falciparum malaria

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Risk factors for gametocyte carriage in Gambian children

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Learning to outwit malaria

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites

30 May 2018

1 reference

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Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa

30 May 2018

1 reference

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pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

30 May 2018

1 reference

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A histidine-rich protein 2-based malaria drug sensitivity assay for field use.

30 May 2018

1 reference

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Multiple transporters associated with malaria parasite responses to chloroquine and quinine

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Artesunate versus artemether for the treatment of recrudescent multidrug-resistant falciparum malaria

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action

30 May 2018

1 reference

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Increased gametocytemia after treatment: an early parasitological indicator of emerging sulfadoxine-pyrimethamine resistance in falciparum malaria

29 November 2018

1 reference

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Malaria eradication back on the table

29 November 2018

1 reference

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Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes.

29 November 2018

1 reference

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Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.

29 November 2018

1 reference

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Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem).

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Risk factors for gametocyte carriage in uncomplicated falciparum malaria.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414557

Field evaluation of drug resistance in malaria. In vitro micro-test

29 November 2018

1 reference

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10.4269/AJTMH.2012.12-0025

29 November 2018

Identifiers

DOI

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