Telomere fusion Dmel_CG6535 (Q29820806)

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Protein found in Drosophila melanogaster

• tefu-PB
• ataxia-telangiectasia mutated
• tefu
• ataxia telangectasia mutated
• CG6535 gene product from transcript CG6535-RB
• ataxia telengiesctasia mutated
• ataxia telangiectasia mutated
• A-T mutated
• drosophila ATM
• telomere fusion
• CG6535-PB

edit

Language	Label	Description	Also known as
English	Telomere fusion Dmel_CG6535	Protein found in Drosophila melanogaster	tefu-PB ataxia-telangiectasia mutated tefu ataxia telangectasia mutated CG6535 gene product from transcript CG6535-RB ataxia telengiesctasia mutated ataxia telangiectasia mutated A-T mutated drosophila ATM telomere fusion CG6535-PB

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q5EAK6

part of

Protein kinase-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q5EAK6

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q5EAK6

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PIK-related kinase family

1 reference

based on heuristic

inferred from protein domain or family

FATC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q5EAK6

encoded by

tefu

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q5EAK6

molecular function

nucleotide binding

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

protein kinase activity

determination method or standard

NAS

1 reference

retrieved

9 May 2019

stated in

Protein kinases and phosphatases in the Drosophila genome

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

NAS

protein serine/threonine kinase activity

determination method or standard

IEA

1 reference

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5EAK6&geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

ATP binding

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

kinase activity

determination method or standard

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

transferase activity

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

histone kinase activity

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IDA

protein binding

determination method or standard

IPI

1 reference

retrieved

5 June 2018

stated in

Protein interaction mapping: a Drosophila case study

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5EAK6&geneProductId=UniProtKB:Q5EAK6

determination method or standard

IPI

protein serine/threonine kinase activity

determination method or standard

IBA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

cell component

telomere

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

nucleus

determination method or standard

IDA

IEA

2 references

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5EAK6&geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

5 June 2018

stated in

TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5EAK6&geneProductId=UniProtKB:Q5EAK6

determination method or standard

IDA

chromosome

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

nucleus

determination method or standard

IBA

IDA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

9 May 2019

stated in

TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

biological process

meiotic DNA double-strand break processing

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IDA

telomere maintenance

determination method or standard

IMP

2 references

retrieved

5 June 2018

stated in

Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5EAK6&geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

5 June 2018

stated in

Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5EAK6&geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

protein phosphorylation

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

cellular response to DNA damage stimulus

determination method or standard

IEA

1 reference

retrieved

5 June 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5EAK6&geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

cell cycle

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

mitotic cell cycle checkpoint signaling

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IGI

multicellular organism development

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

telomere capping

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

phosphorylation

determination method or standard

IEA

NAS

2 references

retrieved

9 May 2019

stated in

Protein kinases and phosphatases in the Drosophila genome

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

NAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

oocyte karyosome formation

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IDA

response to caffeine

determination method or standard

IGI

1 reference

retrieved

9 May 2019

stated in

The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IGI

negative regulation of glial cell apoptotic process

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

photoreceptor cell maintenance

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

negative regulation of innate immune response

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

chromosome organization

determination method or standard

IMP

4 references

retrieved

9 May 2019

stated in

The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

9 May 2019

stated in

The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

9 May 2019

stated in

ATM is required for telomere maintenance and chromosome stability during Drosophila development.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

9 May 2019

stated in

Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

negative regulation of neuron death

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

chromatin organization

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

mitotic G2 DNA damage checkpoint signaling

determination method or standard

IMP

1 reference

retrieved

9 May 2019

stated in

Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

DNA damage checkpoint signaling

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

telomere maintenance

determination method or standard

IBA

IMP

3 references

retrieved

8 April 2019

stated in

Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

8 April 2019

stated in

Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

cellular response to DNA damage stimulus

determination method or standard

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q5EAK6

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

intrinsic apoptotic signaling pathway in response to DNA damage

determination method or standard

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

negative regulation of TORC1 signaling

determination method or standard

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

DNA damage checkpoint signaling

determination method or standard

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

telomere maintenance

determination method or standard

IBA

IEA

IMP

4 references

retrieved

9 May 2019

stated in

Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

9 May 2019

stated in

Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IMP

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IBA

DNA repair

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

response to ionizing radiation

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5EAK6

determination method or standard

IEA

has part(s)

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q5EAK6

FATC domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q5EAK6

PIK-related kinase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q5EAK6

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q5EAK6

Identifiers

RefSeq protein ID

NP_001036712

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

41839

UniProt protein ID

Q5EAK6

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q5EAK6

Ensembl protein ID

FBpp0110174

1 reference

stated in

ensembl Release 106

Ensembl protein ID

FBpp0110174

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q29820806&oldid=2030310314"