Slit Dmel_CG43758 (Q29820548)

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Protein found in Drosophila melanogaster

CG43758-PD
CG43758-PA
CG43758-PB
sli
sli-PB
sli-PD
SGP cluster fusion defects 3
sli-PA
CG43758-PC
CG43758-PF
sli-PF
CG43758-PE
CG43758 gene product from transcript CG43758-RD
sli-PC
lethal (2) 05248
sli-PE
slit

Language	Label	Description	Also known as
English	Slit Dmel_CG43758	Protein found in Drosophila melanogaster	CG43758-PD CG43758-PA CG43758-PB sli sli-PB sli-PD SGP cluster fusion defects 3 sli-PA CG43758-PC CG43758-PF sli-PF CG43758-PE CG43758 gene product from transcript CG43758-RD sli-PC lethal (2) 05248 sli-PE slit

Statements

1 reference

25 May 2022

UniProt protein ID

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

Laminin G domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cystine knot, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

calcium ion binding

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

heparin binding

determination method or standard

1 reference

8 April 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

Roundabout binding

determination method or standard

3 references

9 May 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila Robo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

plasma membrane

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

Slit-Robo signaling complex

determination method or standard

1 reference

9 May 2019

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

biological process

neuron migration

determination method or standard

1 reference

9 May 2019

Roundabout 2 regulates migration of sensory neurons by signaling in trans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

outflow tract morphogenesis

determination method or standard

1 reference

9 May 2019

Cellular components and signals required for the cardiac outflow tract assembly in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

multicellular organism development

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

nervous system development

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

determination method or standard

7 references

9 May 2019

Repellent signaling by Slit requires the leucine-rich repeats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Integrins regulate responsiveness to slit repellent signals.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Slit is the midline repellent for the robo receptor in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Repellent signaling by Slit requires the leucine-rich repeats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Repellent signaling by Slit requires the leucine-rich repeats.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

epithelial cell migration, open tracheal system

determination method or standard

1 reference

9 May 2019

Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

salivary gland boundary specification

determination method or standard

1 reference

9 May 2019

NETRIN and SLIT guide salivary gland migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

digestive tract mesoderm development

determination method or standard

1 reference

9 May 2019

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

mesoderm migration involved in gastrulation

determination method or standard

mesodermal cell migration

determination method or standard

1 reference

9 May 2019

Slit is the midline repellent for the robo receptor in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

glial cell migration

determination method or standard

1 reference

9 May 2019

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

gonad development

determination method or standard

1 reference

9 May 2019

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

regulation of epithelial cell migration

determination method or standard

1 reference

9 May 2019

Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

axon midline choice point recognition

determination method or standard

6 references

9 May 2019

beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Abelson tyrosine kinase is required to transduce midline repulsive cues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

positive regulation of cell-cell adhesion

determination method or standard

1 reference

9 May 2019

Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

cell differentiation

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

neuron differentiation

determination method or standard

1 reference

9 May 2019

Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

embryonic heart tube development

determination method or standard

3 references

9 May 2019

Slit and Robo control cardiac cell polarity and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Slit coordinates cardiac morphogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

9 May 2019

Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

Roundabout signaling pathway

determination method or standard

1 reference

9 May 2019

Slit is the midline repellent for the robo receptor in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

dendrite morphogenesis

determination method or standard

1 reference

9 May 2019

Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

induction of negative chemotaxis

determination method or standard

1 reference

9 May 2019

slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

regulation of epithelial cell migration, open tracheal system

determination method or standard

1 reference

9 May 2019

Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

synaptic target inhibition

determination method or standard

1 reference

9 May 2019

Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

positive regulation of cell migration

determination method or standard

1 reference

9 May 2019

Guidance signalling regulates leading edge behaviour during collective cell migration of cardiac cells in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24014

determination method or standard

EGF-like calcium-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

Laminin G domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

cysteine-rich flanking region, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

leucine-rich repeat N-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

leucine-rich repeat, typical subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

Cystine knot, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

Leucine-rich repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P24014

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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