Immune deficiency Dmel_CG5576 (Q29817044)

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Protein found in Drosophila melanogaster

• imd-PB
• immune deficient
• immunodeficiency
• CG5576-PA
• imd
• CG5576-PB
• imd-PA
• CG5576 gene product from transcript CG5576-RB
• immune deficiency

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Language	Label	Description	Also known as
English	Immune deficiency Dmel_CG5576	Protein found in Drosophila melanogaster	imd-PB immune deficient immunodeficiency CG5576-PA imd CG5576-PB imd-PA CG5576 gene product from transcript CG5576-RB immune deficiency

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q7K4Z4

part of

Death-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q7K4Z4

Death domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q7K4Z4

encoded by

imd

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q7K4Z4

molecular function

protein binding

determination method or standard

IPI

2 references

retrieved

8 April 2019

stated in

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

GOA

curator

UniProt

UniProt protein ID

Q7K4Z4

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IPI

retrieved

8 April 2019

stated in

Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IPI

death domain binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IPI

cell component

intracellular anatomical structure

determination method or standard

NAS

1 reference

retrieved

16 July 2018

stated in

Role of Toll-like receptors in pathogen recognition.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4

determination method or standard

NAS

cytosol

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

TAS

biological process

positive regulation of defense response to virus by host

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

defense response

determination method or standard

TAS

1 reference

retrieved

7 November 2018

stated in

The antimicrobial host defense of Drosophila.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4

determination method or standard

TAS

immune response

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

humoral immune response

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Characterization of an immunodeficiency mutant in Drosophila.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

positive regulation of antibacterial peptide biosynthetic process

determination method or standard

IMP

2 references

retrieved

8 April 2019

stated in

Regulated nuclear import of Rel proteins in the Drosophila immune response

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

retrieved

8 April 2019

stated in

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Iap2 is required for a sustained response in the Drosophila Imd pathway.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

signal transduction

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IEA

nervous system development

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

RNA interference screen to identify genes required for Drosophila embryonic nervous system development.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

response to bacterium

determination method or standard

NAS

1 reference

retrieved

8 April 2019

stated in

Flies kNOw how to signal

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

NAS

antimicrobial humoral response

determination method or standard

IGI

IMP

2 references

retrieved

7 November 2018

stated in

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

retrieved

7 November 2018

stated in

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IGI

antibacterial humoral response

determination method or standard

IMP

2 references

retrieved

8 April 2019

stated in

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

retrieved

8 April 2019

stated in

Characterization of an immunodeficiency mutant in Drosophila.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

intracellular signal transduction

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Drosophila: the genetics of innate immune recognition and response

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

TAS

defense response to bacterium

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

The evolution and genetics of innate immunity

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

TAS

innate immune response

determination method or standard

NAS

1 reference

retrieved

16 July 2018

stated in

The complexity of genetic variation in a simple immune system

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4

determination method or standard

NAS

positive regulation of innate immune response

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

defense response to Gram-negative bacterium

determination method or standard

TAS

2 references

retrieved

8 April 2019

stated in

Role of Toll-like receptors in pathogen recognition.

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

TAS

retrieved

8 April 2019

stated in

Drosophila: the genetics of innate immune recognition and response

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

TAS

peptidoglycan recognition protein signaling pathway

determination method or standard

IMP

3 references

retrieved

8 April 2019

stated in

Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study

GOA

curator

UniProt

UniProt protein ID

Q7K4Z4

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

retrieved

8 April 2019

stated in

The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

retrieved

8 April 2019

stated in

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

immune system process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q7K4Z4

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IEA

innate immune response

determination method or standard

IEA

NAS

2 references

retrieved

1 January 2018

stated in

The complexity of genetic variation in a simple immune system

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4

determination method or standard

NAS

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q7K4Z4

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IEA

positive regulation of antibacterial peptide production

determination method or standard

IGI

1 reference

retrieved

8 April 2019

stated in

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IGI

antimicrobial humoral response

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

GOA

curator

FlyBase

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IMP

innate immune response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q7K4Z4

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4

determination method or standard

IEA

has part(s)

Death domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q7K4Z4

Identifiers

RefSeq protein ID

NP_001286572

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

44339

NP_573394

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

44339

UniProt protein ID

Q7K4Z4

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q7K4Z4

Ensembl protein ID

FBpp0311815

1 reference

stated in

ensembl Release 106

Ensembl protein ID

FBpp0311815

FBpp0085904

1 reference

stated in

ensembl Release 106

Ensembl protein ID

FBpp0085904

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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