Serine peptidase inhibitor, Kazal type 5 (Q29530706)

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mammalian protein found in Mus musculus

• Spink5
• Netherton syndrome
• serine protease inhibitor, Kazal type 5
• serine protease inhibitor Kazal-type 5

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Language	Label	Description	Also known as
English	Serine peptidase inhibitor, Kazal type 5	mammalian protein found in Mus musculus	Spink5 Netherton syndrome serine protease inhibitor, Kazal type 5 serine protease inhibitor Kazal-type 5

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q148R4

part of

Kazal domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q148R4

Kazal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

house mouse

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q148R4

encoded by

Spink5

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q148R4

molecular function

serine-type endopeptidase inhibitor activity

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

peptidase inhibitor activity

determination method or standard

IMP

1 reference

retrieved

14 February 2019

stated in

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IMP

cell component

extracellular region

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

cytoplasm

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

endoplasmic reticulum

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

endoplasmic reticulum membrane

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

cytosol

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

cell cortex

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

intracellular membrane-bounded organelle

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

perinuclear region of cytoplasm

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

epidermal lamellar body

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

biological process

negative regulation of antibacterial peptide production

determination method or standard

IMP

1 reference

retrieved

14 February 2019

stated in

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

GOA

curator

UniProt

UniProt protein ID

Q148R4

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IMP

epidermal cell differentiation

determination method or standard

IEA

ISO

2 references

retrieved

14 February 2019

stated in

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

ISO

retrieved

14 February 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IEA

regulation of cell adhesion

determination method or standard

IMP

1 reference

retrieved

14 February 2019

stated in

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IMP

negative regulation of proteolysis

determination method or standard

IMP

1 reference

retrieved

14 February 2019

stated in

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IMP

negative regulation of serine-type endopeptidase activity

determination method or standard

IMP

1 reference

retrieved

14 February 2019

stated in

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

GOA

curator

UniProt

UniProt protein ID

Q148R4

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IMP

negative regulation of serine-type peptidase activity

determination method or standard

IMP

1 reference

retrieved

14 February 2019

stated in

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q148R4

determination method or standard

IMP

has part(s)

Kazal domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q148R4

Identifiers

RefSeq protein ID

NP_001074649

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

72432

XP_006526342

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

72432

XP_006526343

1 reference

stated in

NCBI Gene

retrieved

20 March 2022

Entrez Gene ID

72432

UniProt protein ID

Q148R4

1 reference

stated in

UniProt

retrieved

25 May 2022

UniProt protein ID

Q148R4

Ensembl protein ID

ENSMUSP00000066214

1 reference

stated in

ensembl Release 106

Ensembl protein ID

ENSMUSP00000066214

 

Sitelinks

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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