A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia (Q28820781)

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25 March 2020

title

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia (English)

1 reference

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25 March 2020

1 reference

acute myeloid leukemia

1 reference

1 reference

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25 March 2020

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25 March 2020

Gregory A Reed

1 reference

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25 March 2020

Gary J Schiller

1 reference

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25 March 2020

Suman Kambhampati

1 reference

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25 March 2020

Dan Douer

1 reference

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25 March 2020

Mark D Minden

1 reference

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25 March 2020

Karen W Yee

1 reference

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25 March 2020

Joseph Brandwein

1 reference

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25 March 2020

Yulia Jitkova

1 reference

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25 March 2020

Marcela Gronda

1 reference

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25 March 2020

Rose Hurren

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25 March 2020

Aisha Shamas-Din

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25 March 2020

Andre C Schuh

1 reference

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25 March 2020

Martin S Tallman

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25 March 2020

language of work or name

English

0 references

publication date

13 October 2016

1 reference

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25 March 2020

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25 March 2020

volume

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25 March 2020

issue

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25 March 2020

page(s)

3031-3040

1 reference

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Re-defining tigecycline therapy

25 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity

16 March 2017

1 reference

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Functional, biophysical, and structural bases for antibacterial activity of tigecycline

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430606

Pharmacokinetics of Tigecycline after Single and Multiple Doses in Healthy Subjects

16 March 2017

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Efficacy of tigecycline for secondary Acinetobacter bacteremia and factors associated with treatment failure.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

3 June 2018

Tigecycline: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Dysregulation of the mevalonate pathway promotes transformation

3 June 2018

1 reference

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Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Tigecycline: a critical analysis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Pharmacokinetics, pharmacodynamics, safety and tolerability of tigecycline

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Pharmacokinetic/pharmacodynamic profile for tigecycline-a new glycylcycline antimicrobial agent

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Effects of age and sex on single-dose pharmacokinetics of tigecycline in healthy subjects

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Pharmacokinetic profile of tigecycline in serum and skin blister fluid of healthy subjects after multiple intravenous administrations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Initiation and elongation factors in mammalian mitochondrial protein biosynthesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Properties of human mitochondrial ribosomes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

3 June 2018

Acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

Chloramphenicol toxicity: 25 years of research.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5119957

A novel mitochondrial DNA mutation in COX1 leads to strokes, seizures, and lactic acidosis.

3 June 2018

1 reference

Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA.

21 January 2018

1 reference

Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936.

21 January 2018

1 reference

The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/27734609

21 January 2018

1 reference

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Tigecycline pharmacokinetics in subjects with various degrees of renal function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27734609

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Therapeutic potential of mitochondrial translation inhibition for treatment of acute myeloid leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27734609

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CAM4.845

2 references

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25 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27734609%20AND%20SRC:MED&resulttype=core&format=json

25 March 2020

PubMed publication ID

27734609

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27734609%20AND%20SRC:MED&resulttype=core&format=json