Interaction of p53 with its consensus DNA-binding site (Q28639970)

3 February 2017

title

Interaction of p53 with its consensus DNA-binding site (English)

1 reference

3 February 2017

Y. Wang

1 reference

3 February 2017

J. F. Schwedes

1 reference

3 February 2017

D. Parks

1 reference

3 February 2017

K. Mann

1 reference

3 February 2017

P. Tegtmeyer

1 reference

3 February 2017

language of work or name

English

0 references

publication date

1 April 1995

1 reference

Molecular and Cellular Biology

3 February 2017

published in

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3 February 2017

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3 February 2017

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3 February 2017

page(s)

2157–2165

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High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

3 February 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

17 March 2017

1 reference

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Allosteric activation of latent p53 tetramers

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

p53 oligomerization and DNA looping are linked with transcriptional activation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Identification of p53 as a sequence-specific DNA-binding protein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Oncogenic forms of p53 inhibit p53-regulated gene expression

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Definition of a consensus binding site for p53

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

17 March 2017

1 reference

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The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Identification and analysis of all components of a gel retardation assay by combination with immunoblotting.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

The tumor suppressor p53.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

A comparison of the biological activities of wild-type and mutant p53.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Sequence-specific transcriptional activation is essential for growth suppression by p53.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

p53 domains: structure, oligomerization, and transformation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Database of p53 gene somatic mutations in human tumors and cell lines

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

p53 tagged sites from human genomic DNA.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Presence of a potent transcription activating sequence in the p53 protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

A transcriptionally active DNA-binding site for human p53 protein complexes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Formation of stable p53 homotetramers and multiples of tetramers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

p53 function and dysfunction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

p53 domains: suppression, transformation, and transactivation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

p53 domains: identification and characterization of two autonomous DNA-binding regions.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=230443

Wild-type p53 activates transcription in vitro

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/7891710

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The amino acid sequence of murine p53 determined from a c-DNA clone

1 reference

https://pubmed.ncbi.nlm.nih.gov/7891710

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

https://pubmed.ncbi.nlm.nih.gov/7891710