Vav1: a key signal transducer downstream of the TCR (Q28610412)

3 February 2017

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Europe PubMed Central

title

Vav1: a key signal transducer downstream of the TCR (English)

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ORCID Public Data File 2021

3 February 2017

Antonella Prisco

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Laurence Ardouin

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author name string

Victor L. J. Tybulewicz

series ordinal

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3 February 2017

Antonella Prisco

series ordinal

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3 February 2017

Lucinda F. Reynolds

series ordinal

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3 February 2017

publication date

1 April 2003

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3 February 2017

April 2003

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published in

Immunological Reviews

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3 February 2017

volume

192

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3 February 2017

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42–52

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Selection of the T cell repertoire.

3 February 2017

42-52

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cites work

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

On the brink of becoming a T cell.

21 January 2018

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 January 2018

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Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

21 January 2018

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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Proto-vav and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Lck regulates Vav activation of members of the Rho family of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Structural determinants for the biological activity of Vav proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Optic flow: A brain region devoted to optic flow analysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Vav regulates peptide-specific apoptosis in thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Tec kinases: modulators of lymphocyte signaling and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Regulation of leukocyte integrin function: affinity vs. avidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

A functional T-cell receptor signaling pathway is required for p95vav activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Specific subdomains of Vav differentially affect T cell and NK cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Novel recognition mode between Vav and Grb2 SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

p95vav associates with the nuclear protein Ku-70

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

Maintaining the norm: T-cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00032.X

7 January 2021

10.1034/J.1600-065X.2003.00032.X

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1 reference