The interferon-inducible gene viperin restricts West Nile virus pathogenesis (Q28594932)

1 February 2017

title

The interferon-inducible gene viperin restricts West Nile virus pathogenesis (English)

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Radical S-adenosyl methionine domain containing 2

1 February 2017

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GOA release 2020-03-11

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Herbert W. Virgin

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1 February 2017

Larissa B. Thackray

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1 February 2017

Kristy J. Szretter

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1 February 2017

James D. Brien

series ordinal

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1 February 2017

Peter Cresswell

series ordinal

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1 February 2017

publication date

1 November 2011

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1 February 2017

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1 February 2017

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1 February 2017

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1 February 2017

page(s)

11557–11566

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Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

1 February 2017

cites work

1 reference

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A diverse range of gene products are effectors of the type I interferon antiviral response

17 March 2017

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Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

17 March 2017

1 reference

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The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells

17 March 2017

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The antiviral protein viperin is a radical SAM enzyme

17 March 2017

1 reference

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IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

17 March 2017

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The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix

17 March 2017

1 reference

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Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

17 March 2017

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The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

17 March 2017

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Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

17 March 2017

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The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion

17 March 2017

1 reference

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Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1

17 March 2017

1 reference

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The Cellular Antiviral Protein Viperin Is Attenuated by Proteasome-Mediated Protein Degradation in Japanese Encephalitis Virus-Infected Cells

17 March 2017

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Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus

17 March 2017

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The lipid droplet is an important organelle for hepatitis C virus production

17 March 2017

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Identification and characterization of interferon-induced proteins that inhibit alphavirus replication

17 March 2017

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Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent Mechanisms

17 March 2017

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Tissue tropism and neuroinvasion of West Nile virus do not differ for two mouse strains with different survival rates

17 March 2017

1 reference

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TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5

17 March 2017

1 reference

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Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion

17 March 2017

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PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

17 March 2017

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Protective immune responses against West Nile virus are primed by distinct complement activation pathways

17 March 2017

1 reference

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The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells

17 March 2017

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Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector

17 March 2017

1 reference

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Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis

17 March 2017

1 reference

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Epidemiology and transmission dynamics of West Nile virus disease

17 March 2017

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Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

17 March 2017

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B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus.

17 March 2017

1 reference

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A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice

17 March 2017

1 reference

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Positional cloning of the murine flavivirus resistance gene

17 March 2017

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Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Role of CD8+ T cells in control of West Nile virus infection

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Transgenic expression of full-length 2',5'-oligoadenylate synthetase 1b confers to BALB/c mice resistance against West Nile virus-induced encephalitis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

The lectin pathway of complement activation contributes to protection from West Nile virus infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

The Interferon Inducible Gene: Viperin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

New developments in the induction and antiviral effectors of type I interferon

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Recognition of viruses by cytoplasmic sensors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Mechanisms of evasion of the type I interferon antiviral response by flaviviruses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Small self-RNA generated by RNase L amplifies antiviral innate immunity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

West Nile virus infections projected from blood donor screening data, United States, 2003

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Neurons produce type I interferon during viral encephalitis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Genetic and phenotypic variation of West Nile virus in New York, 2000-2003.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Infection and injury of neurons by West Nile encephalitis virus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Beta interferon controls West Nile virus infection and pathogenesis in mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3209274

Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21880757