Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling (Q28584278)

31 January 2017

title

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling (English)

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31 January 2017

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Jerrold M. Olefsky

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31 January 2017

Satoshi Ugi

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31 January 2017

Takeshi Imamura

series ordinal

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31 January 2017

William Ricketts

series ordinal

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31 January 2017

language of work or name

English

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publication date

1 April 2002

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Molecular and Cellular Biology

31 January 2017

published in

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31 January 2017

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31 January 2017

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31 January 2017

page(s)

2375–2387

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

31 January 2017

cites work

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Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors

17 March 2017

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The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

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The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

17 March 2017

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Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins

17 March 2017

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B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein

17 March 2017

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Protein modules and signalling networks

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Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor

17 March 2017

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17 March 2017

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Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

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Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways

29 September 2017

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A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

29 September 2017

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Regulation of protein kinase cascades by protein phosphatase 2A.

29 September 2017

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Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 smallt to promote cell growth and NF-kappa B activation

29 September 2017

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Novel protein serine/threonine phosphatases: Variety is the spice of life

29 September 2017

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Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kappaB activation

29 September 2017

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Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin

29 September 2017

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

29 September 2017

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Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling

29 September 2017

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Effect of tumor necrosis factor-alpha on insulin-stimulated mitogen-activated protein kinase cascade in cultured rat skeletal muscle cells

29 September 2017

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Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

29 September 2017

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High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms

29 September 2017

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The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

29 September 2017

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29 September 2017

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Comparison of heterotrimeric protein phosphatase 2A containing different B subunits.

29 September 2017

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29 September 2017

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Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

29 September 2017

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Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

29 September 2017

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Constant expression and activity of protein phosphatase 2A in synchronized cells

29 September 2017

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The roles of the simian virus 40 tumor antigens in transformation of chinese hamster lung cells

29 September 2017

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Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells

29 September 2017

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Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.

29 September 2017

1 reference

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Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Phosphatase 2A associated with polyomavirus small-T or middle-T antigen is an okadaic acid-sensitive tyrosyl phosphatase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Regulation of protein phosphatase 1 and 2A activities by insulin during myogenesis in rat skeletal muscle cells in culture.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Interleukin-2-induced tyrosine phosphorylation of p52shc in T lymphocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Control of protein phosphatase 2A by simian virus 40 small-t antigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

3 June 2018

1 reference

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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.

27 November 2018

1 reference

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Cell cycle-dependent activation of Ras.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

Neurofilament-associated protein phosphatase 2A: its possible role in preserving neurofilaments in filamentous states.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133677

cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells

27 November 2018

1 reference

12 December 2020

Insulin-induced desensitization of extracellular signal-regulated kinase activation results from an inhibition of Raf activity independent of Ras activation and dissociation of the Grb2-SOS complex

1 reference

12 December 2020

Effects of regulatory subunits on the kinetics of protein phosphatase 2A

1 reference

12 December 2020

Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart

1 reference

12 December 2020

10.1128/MCB.22.7.2375-2387.2002

Identifiers

DOI

0 references

PMC publication ID

133677

0 references

1 reference