The structure and function of glutamate receptor ion channels (Q28579343)

31 January 2017

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Europe PubMed Central

title

The structure and function of glutamate receptor ion channels (English)

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31 January 2017

Dean R. Madden

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31 January 2017

language of work or name

English

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publication date

1 February 2002

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Nature Reviews Neuroscience

31 January 2017

published in

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31 January 2017

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31 January 2017

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31 January 2017

page(s)

91–101

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

31 January 2017

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Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis

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Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices

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Mechanism of corepressor-mediated specific DNA binding by the purine repressor

31 March 2020

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Crystal structure of the lactose operon repressor and its complexes with DNA and inducer

31 March 2020

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Conformational changes of ribose-binding protein and two related repressors are tailored to fit the functional need

31 March 2020

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A Molecular Envelope of the Ligand-Binding Domain of a Glutamate Receptor in the Presence and Absence of Agonist†

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Crystal structures of the maltodextrin/maltose-binding protein complexed with reduced oligosaccharides: flexibility of tertiary structure and ligand binding

31 March 2020

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Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity

31 March 2020

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Dominant role of local dipolar interactions in phosphate binding to a receptor cleft with an electronegative charge surface: equilibrium, kinetic, and crystallographic studies

31 March 2020

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Spontaneous openings of NMDA receptor channels in cultured rat hippocampal neurons

31 March 2020

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Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene

31 March 2020

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Neuronal control of locomotion in C. elegans is modified by a dominant mutation in the GLR-1 ionotropic glutamate receptor

31 March 2020

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Mutation of a glutamate receptor motif reveals its role in gating and delta2 receptor channel properties.

31 March 2020

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Dominance of the lurcher mutation in heteromeric kainate and AMPA receptor channels

31 March 2020

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Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

31 March 2020

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The macro- and microarchitectures of the ligand-binding domain of glutamate receptors

31 March 2020

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Allosteric receptors after 30 years

31 March 2020

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Mapping the conformational wave of acetylcholine receptor channel gating

31 March 2020

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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

31 March 2020

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The Lurcher mutation of an alpha-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid receptor subunit enhances potency of glutamate and converts an antagonist to an agonist

31 March 2020

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Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating

31 March 2020

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Intermediate conductances during deactivation of heteromultimeric Shaker potassium channels

31 March 2020

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Selectivity Changes during Activation of Mutant Shaker Potassium Channels

31 March 2020

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High specificity of a phosphate transport protein determined by hydrogen bonds

31 March 2020

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Ligands for glutamate receptors: design and therapeutic prospects

31 March 2020

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31 March 2020

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Evidence for a tetrameric structure of recombinant NMDA receptors.

31 March 2020

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A tetrameric subunit stoichiometry for a glutamate receptor-channel complex

31 March 2020

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First images of a glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers

31 March 2020

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Domain interactions regulating ampa receptor desensitization.

31 March 2020

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Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers

31 March 2020

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Structural rearrangements underlying K+-channel activation gating

31 March 2020

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Kinetic analysis of interactions between kainate and AMPA: Evidence for activation of a single receptor in mouse hippocampal neurons

31 March 2020

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Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9‐aminoacridine

31 March 2020

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AMPA receptors and bacterial periplasmic amino acid-binding proteins share the ionic mechanism of ligand recognition

31 March 2020

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Energetic optimization of ion conduction rate by the K+ selectivity filter

31 March 2020

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Ion conduction pore is conserved among potassium channels

31 March 2020

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Acetylcholine receptor channel imaged in the open state

31 March 2020

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Permeability of the endplate membrane activated by acetylcholine to some organic cations

31 March 2020

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The permeability of the endplate channel to organic cations in frog muscle

31 March 2020

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Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations

31 March 2020

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Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues

31 March 2020

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Dimensions of the narrow portion of a recombinant NMDA receptor channel

31 March 2020

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Channel-lining residues of the AMPA receptor M2 segment: structural environment of the Q/R site and identification of the selectivity filter.

31 March 2020

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The Ca channel in skeletal muscle is a large pore

31 March 2020

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A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K + Channels

31 March 2020

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Mutations in the K+ channel signature sequence

31 March 2020

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Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

31 March 2020

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Cloning by functional expression of a member of the glutamate receptor family

31 March 2020

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A family of AMPA-selective glutamate receptors

31 March 2020

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Molecular cloning and functional expression of glutamate receptor subunit genes

31 March 2020

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31 March 2020

Self-regulating synapses

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Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development

31 March 2020

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Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

31 March 2020

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Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

31 March 2020

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Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit

31 March 2020

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The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits.

31 March 2020

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Molecular physiology of kainate receptors

31 March 2020

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Molecular cloning and characterization of the rat NMDA receptor

31 March 2020

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Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

31 March 2020

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Heteromeric NMDA receptors: molecular and functional distinction of subtypes

31 March 2020

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Molecular diversity of the NMDA receptor channel

31 March 2020

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Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

31 March 2020

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Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain

31 March 2020

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Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner

31 March 2020

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Glycine potentiates the NMDA response in cultured mouse brain neurons

31 March 2020

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D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

31 March 2020

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Magnesium gates glutamate-activated channels in mouse central neurones

31 March 2020

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Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

31 March 2020

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Selective RNA editing and subunit assembly of native glutamate receptors

31 March 2020

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The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

31 March 2020

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The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family

31 March 2020

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Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice

31 March 2020

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Molecular cloning of an invertebrate glutamate receptor subunit expressed in Drosophila muscle

31 March 2020

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Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor

31 March 2020

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Glutamate-receptor genes in plants

31 March 2020

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Molecular evolution of glutamate receptors: a primitive signaling mechanism that existed before plants and animals diverged

31 March 2020

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Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors

31 March 2020

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A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein

31 March 2020

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