Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. (Q28577842)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

title

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Ghislaine Fontes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Julie Amyot

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Caroline Tremblay

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Meriem Semache

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Violet Roskens

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Derek K Hagman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Martin G Latour

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Swarup K Chakrabarti

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

James A Lausier

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Raghavendra G Mirmira

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Thomas L Jetton

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

language of work or name

English

0 references

publication date

8 November 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

number of pages

1 reference

inferred from page(s)

published in

Diabetes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

page(s)

424-431

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site

10 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Primer3 on the WWW for general users and for biologist programmers

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

17 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

17 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Glucose infusion in mice: a new model to induce beta-cell replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Islet beta cell failure in type 2 diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Inhibition of Insulin Secretion by Leptin in Normal Rodent Islets of Langerhans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Metabolic adaptations to chronic glucose infusion in rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Specific and Combined Effects of Insulin and Glucose on Functional Pancreatic β-Cell Mass in Vivo in Adult Rats

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2979006

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

27 November 2018

1 reference

12 December 2020

A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

1 reference

12 December 2020

Effect of prolonged in vivo glucose infusion on insulin secretion in rats with previous glucose intolerance

1 reference

12 December 2020

Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels

1 reference

12 December 2020

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement

1 reference

12 December 2020

Beta-cell dysfunction in 48-hour glucose-infused rats is not a consequence of elevated plasma lipid or islet triglyceride levels

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB07-1285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PubMed publication ID

17991758

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991758%20AND%20SRC:MED&resulttype=core&format=json