Protein tyrosine phosphatase, receptor type Z1 (Q28562642)

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mammalian protein found in Rattus norvegicus

protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Ptprz1
PTP zeta
3F8 chondroitin sulfate proteoglycan
6B4 proteoglycan
receptor-type tyrosine-protein phosphatase zeta
R-PTP-zeta
3H1 keratan sulfate proteoglycan

Language	Label	Description	Also known as
English	Protein tyrosine phosphatase, receptor type Z1	mammalian protein found in Rattus norvegicus	protein tyrosine phosphatase, receptor-type, Z polypeptide 1 Ptprz1 PTP zeta 3F8 chondroitin sulfate proteoglycan 6B4 proteoglycan receptor-type tyrosine-protein phosphatase zeta R-PTP-zeta 3H1 keratan sulfate proteoglycan

Statements

1 reference

25 May 2022

UniProt protein ID

Fibronectin type III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

Alpha carbonic anhydrase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

Protein-tyrosine phosphatase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tyrosine specific protein phosphatases domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTP type protein phosphatase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Alpha carbonic anhydrase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

phosphoprotein phosphatase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

protein tyrosine phosphatase activity

determination method or standard

6 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

protein binding

determination method or standard

2 references

14 February 2019

Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

hydrolase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

fibroblast growth factor binding

determination method or standard

1 reference

14 February 2019

The core protein of the chondroitin sulfate proteoglycan phosphacan is a high-affinity ligand of fibroblast growth factor-2 and potentiates its mitogenic activity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

extracellular region

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

extracellular space

determination method or standard

1 reference

14 February 2019

Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

determination method or standard

1 reference

14 February 2019

Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

plasma membrane

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

integral component of membrane

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

determination method or standard

1 reference

14 February 2019

Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

determination method or standard

1 reference

14 February 2019

Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

determination method or standard

1 reference

14 February 2019

Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

determination method or standard

1 reference

14 February 2019

Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

determination method or standard

1 reference

14 February 2019

6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

intrinsic component of plasma membrane

determination method or standard

1 reference

14 February 2019

Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

ruffle membrane

determination method or standard

1 reference

14 February 2019

Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

determination method or standard

1 reference

14 February 2019

6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

dendritic spine

determination method or standard

1 reference

14 February 2019

Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

postsynaptic membrane

determination method or standard

1 reference

14 February 2019

Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

perineuronal net

determination method or standard

1 reference

14 February 2019

Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

glutamatergic synapse

determination method or standard

1 reference

14 February 2019

Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

integral component of postsynaptic density membrane

determination method or standard

1 reference

14 February 2019

Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

biological process

protein dephosphorylation

determination method or standard

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

axonal fasciculation

determination method or standard

1 reference

14 February 2019

Chondroitin sulfate proteoglycan phosphacan associates with parallel fibers and modulates axonal extension and fasciculation of cerebellar granule cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

brain development

determination method or standard

1 reference

14 February 2019

Characterization and developmental regulation of proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta isoforms

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

learning or memory

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

14 February 2019

Two types of brain chondroitin sulfate proteoglycan: their distribution and possible functions in the rat embryo

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

visual learning

determination method or standard

1 reference

14 February 2019

Hippocampal gene expression profiling in spatial discrimination learning

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

negative regulation of cell-substrate adhesion

determination method or standard

1 reference

14 February 2019

Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of neuron projection development

determination method or standard

1 reference

14 February 2019

6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

dephosphorylation

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

hippocampus development

determination method or standard

1 reference

14 February 2019

Chondroitin sulfate proteoglycan expression pattern in hippocampal development: potential regulation of axon tract formation

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of cell migration

determination method or standard

1 reference

14 February 2019

Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

peptidyl-tyrosine dephosphorylation

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

14 February 2019

Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of fibroblast proliferation

determination method or standard

1 reference

14 February 2019

The core protein of the chondroitin sulfate proteoglycan phosphacan is a high-affinity ligand of fibroblast growth factor-2 and potentiates its mitogenic activity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

neuron development

determination method or standard

1 reference

14 February 2019

Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

regulation of dendrite morphogenesis

determination method or standard

1 reference

14 February 2019

A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of peptidyl-tyrosine phosphorylation

determination method or standard

1 reference

14 February 2019

6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

regulation of oligodendrocyte progenitor proliferation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of dendrite development

determination method or standard

1 reference

14 February 2019

6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of Schwann cell migration

determination method or standard

1 reference

14 February 2019

Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of neuron death

determination method or standard

1 reference

14 February 2019

Recombinant core protein fragment of phosphacan, a brain specific chondroitin sulfate proteoglycan, promote excitotoxic cell death of cultured rat hippocampal neurons

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

negative regulation of dendrite development

determination method or standard

1 reference

14 February 2019

Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

positive regulation of neuron migration

determination method or standard

1 reference

14 February 2019

Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62656

determination method or standard

Protein-tyrosine phosphatase, catalytic

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

Protein-tyrosine phosphatase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

Tyrosine specific protein phosphatases domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

fibronectin type III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

Alpha carbonic anhydrase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

PTP type protein phosphatase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q62656

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000008719

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000008719

ENSRNOP00000097069

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000097069

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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