ATP binding cassette subfamily C member 2 (Q28559439)

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mammalian protein found in Rattus norvegicus

cMrp2/cMoat canalicular apical conjugate export pump
ATP-binding cassette, subfamily C (CFTR/MRP), member 2
ATP-binding cassette sub-family C member 2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
canalicular multispecific organic anion transporter 1
multidrug resistance-associated protein 2
calicular multispecific organic anion transporter
canalicular multidrug resistance protein
Abcc2

Language	Label	Description	Also known as
English	ATP binding cassette subfamily C member 2	mammalian protein found in Rattus norvegicus	cMrp2/cMoat canalicular apical conjugate export pump ATP-binding cassette, subfamily C (CFTR/MRP), member 2 ATP-binding cassette sub-family C member 2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 canalicular multispecific organic anion transporter 1 multidrug resistance-associated protein 2 calicular multispecific organic anion transporter canalicular multidrug resistance protein Abcc2

Statements

1 reference

17 November 2021

UniProt protein ID

ABC transporter type 1, transmembrane domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63120

Canalicular multispecific organic anion transporter 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63120

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q63120

1 reference

based on heuristic

inferred from protein domain or family

ABC transporter-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

ABC transporter type 1, transmembrane domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ABC transporter, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

protein binding

determination method or standard

1 reference

9 May 2019

NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

ATPase activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

protein domain specific binding

determination method or standard

1 reference

9 May 2019

Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

transmembrane transporter activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

plasma membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

determination method or standard

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

9 May 2019

Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

apical plasma membrane

determination method or standard

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

9 May 2019

NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

9 May 2019

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

brush border membrane

determination method or standard

1 reference

9 May 2019

Function of multidrug resistance-associated protein 2 in acute hepatic failure rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

intercellular canaliculus

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

biological process

xenobiotic transmembrane transport

determination method or standard

1 reference

9 May 2019

Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to oxidative stress

determination method or standard

1 reference

9 May 2019

Oxidative stress and Mrp2 internalization

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

female pregnancy

determination method or standard

1 reference

9 May 2019

The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2)

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to heat

determination method or standard

1 reference

9 May 2019

Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

mercury ion transport

determination method or standard

1 reference

9 May 2019

MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

organic anion transport

determination method or standard

1 reference

9 May 2019

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

canalicular bile acid transport

determination method or standard

1 reference

9 May 2019

Quantification of drug transport function across the multiple resistance-associated protein 2 (Mrp2) in rat livers

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

prostaglandin transport

determination method or standard

1 reference

9 May 2019

Multidrug resistance associated protein 2 mediates transport of prostaglandin E2

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

antibiotic metabolic process

determination method or standard

1 reference

9 May 2019

Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

cellular chloride ion homeostasis

determination method or standard

1 reference

9 May 2019

Mrp2 modulates the activity of chloride channels in isolated hepatocytes

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to methotrexate

determination method or standard

1 reference

9 May 2019

Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

9 May 2019

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to glucagon

determination method or standard

1 reference

9 May 2019

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to estrogen

determination method or standard

1 reference

9 May 2019

Estradiol-17β-D-glucuronide induces endocytic internalization of Bsep in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to arsenic-containing substance

determination method or standard

1 reference

9 May 2019

Effects of MRP2-GSH cotransport system on hepatic arsenic metabolism in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to steroid hormone

determination method or standard

1 reference

9 May 2019

Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

thyroid hormone transport

determination method or standard

1 reference

9 May 2019

Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

cellular response to interleukin-1

determination method or standard

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

cellular response to interleukin-6

determination method or standard

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

cellular response to tumor necrosis factor

determination method or standard

1 reference

9 May 2019

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

cellular response to dexamethasone stimulus

determination method or standard

1 reference

9 May 2019

Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

response to antineoplastic agent

determination method or standard

1 reference

9 May 2019

Effect of 5-fluorouracil treatment on SN-38 absorption from intestine in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

benzylpenicillin metabolic process

determination method or standard

1 reference

9 May 2019

Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63120

determination method or standard

Identifiers

RefSeq protein ID

1 reference

7 September 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

Ensembl protein ID

ENSRNOP00000064799

1 reference

ensembl Release 104

Ensembl protein ID

ENSRNOP00000064799

Sitelinks

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Multilingual sites(0 entries)

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