Rap guanine nucleotide exchange factor 2 (Q28556909)

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mammalian protein found in Rattus norvegicus

Rapgef2
CNrasGEF
rap guanine nucleotide exchange factor 2
ras/Rap1-associating GEF-1
PDZ domain-containing guanine nucleotide exchange factor 1
neural RAP guanine nucleotide exchange protein
Rap guanine nucleotide exchange factor (GEF) 2
cyclic nucleotide ras GEF
rap guanine nucleotide exchange factor 6-like

Language	Label	Description	Also known as
English	Rap guanine nucleotide exchange factor 2	mammalian protein found in Rattus norvegicus	Rapgef2 CNrasGEF rap guanine nucleotide exchange factor 2 ras/Rap1-associating GEF-1 PDZ domain-containing guanine nucleotide exchange factor 1 neural RAP guanine nucleotide exchange protein Rap guanine nucleotide exchange factor (GEF) 2 cyclic nucleotide ras GEF rap guanine nucleotide exchange factor 6-like

Statements

1 reference

17 November 2021

UniProt protein ID

Ubiquitin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

RmlC-like jelly roll fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Ras guanine nucleotide exchange factor domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Rap guanine nucleotide exchange factor 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Cyclic nucleotide-binding-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Ras-associating (RA) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ras guanine-nucleotide exchange factors catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cyclic nucleotide-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ras-like guanine nucleotide exchange factor, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

molecular function

protein binding

determination method or standard

2 references

14 February 2019

nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

14 February 2019

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

protein kinase binding

determination method or standard

1 reference

14 February 2019

Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

PDZ domain binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

beta-1 adrenergic receptor binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

WW domain binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

cell-cell junction

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

neuron projection

determination method or standard

1 reference

14 February 2019

The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

determination method or standard

1 reference

14 February 2019

nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

determination method or standard

1 reference

14 February 2019

nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

protein-containing complex

determination method or standard

1 reference

14 February 2019

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

biological process

blood vessel development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

neuron migration

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

signal transduction

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

neuropeptide signaling pathway

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

small GTPase mediated signal transduction

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

multicellular organism development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

nervous system development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of neuron projection development

determination method or standard

1 reference

14 February 2019

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

cAMP-mediated signaling

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

ventricular system development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

forebrain neuron development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

cell differentiation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

neuron projection development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

brain-derived neurotrophic factor receptor signaling pathway

determination method or standard

1 reference

14 February 2019

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of protein binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

Rap protein signal transduction

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

nerve growth factor signaling pathway

determination method or standard

1 reference

14 February 2019

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

regulation of cell population proliferation

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of GTPase activity

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

14 February 2019

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

14 February 2019

Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of cAMP-mediated signaling

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of protein kinase activity

determination method or standard

negative regulation of melanin biosynthetic process

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

regulation of synaptic plasticity

determination method or standard

1 reference

14 February 2019

Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

negative regulation of dendrite morphogenesis

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

establishment of endothelial barrier

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

cellular response to cAMP

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

cellular response to cGMP

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

adenylate cyclase-activating adrenergic receptor signaling pathway

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

regulation of cell junction assembly

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

cellular response to nerve growth factor stimulus

determination method or standard

1 reference

14 February 2019

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of cAMP-dependent protein kinase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of dendritic cell apoptotic process

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of vasculogenesis

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

positive regulation of neuron migration

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:F1M386

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Ras-like guanine nucleotide exchange factor, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Ras guanine-nucleotide exchange factors catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Cyclic nucleotide-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Ras-associating (RA) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/F1M386

Identifiers

RefSeq protein ID

1 reference

7 September 2021

UniProt protein ID

1 reference

17 November 2021

UniProt protein ID

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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