Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2 (Q28508573)

24 January 2017

title

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2 (English)

1 reference

24 January 2017

main subject

stem cell self-renewal

1 reference

1 reference

Alexey Bersenev

1 reference

24 January 2017

Chao Wu

series ordinal

1 reference

24 January 2017

Joanna Balcerek

series ordinal

1 reference

24 January 2017

Wei Tong

series ordinal

1 reference

24 January 2017

language of work or name

English

0 references

publication date

1 August 2008

1 reference

Journal of Clinical Investigation

24 January 2017

published in

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24 January 2017

volume

118

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24 January 2017

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24 January 2017

page(s)

2832–2844

1 reference

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

24 January 2017

cites work

1 reference

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

19 March 2017

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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways

19 March 2017

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

19 March 2017

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Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta

19 March 2017

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

19 March 2017

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Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk

19 March 2017

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The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

19 March 2017

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Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling

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c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia

19 March 2017

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Jak2 is essential for signaling through a variety of cytokine receptors

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Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

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Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.

7 April 2017

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29 September 2017

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Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal

29 September 2017

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The membrane-proximal region of the thrombopoietin receptor confers its high surface expression by JAK2-dependent and -independent mechanisms

29 September 2017

1 reference

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Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.

29 September 2017

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Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

29 September 2017

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

29 September 2017

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Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis

29 September 2017

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29 September 2017

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Thrombopoietin expands hematopoietic stem cells after transplantation

29 September 2017

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29 September 2017

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29 September 2017

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Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins

29 September 2017

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Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.

29 September 2017

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In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Flow cytometric estimation of DNA and RNA content in intact cells stained with hoechst 33342 and pyronin Y

29 September 2017

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Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

29 September 2017

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Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy

29 September 2017

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Effects of transplantation on the primitive immunohematopoietic stem cell

29 September 2017

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29 September 2017

1 reference

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29 September 2017

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2 June 2018

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Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

2 June 2018

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Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice

27 November 2018

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Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2447929

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

27 November 2018

1 reference

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27 November 2018

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Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice

27 November 2018

1 reference

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27 November 2018

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HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

27 November 2018

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Permanent loss in stem cell self renewal capacity following stress to the marrow

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18618018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18618018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18618018