The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions (Q28507911)

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English	The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions	scientific journal article

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scholarly article

1 reference

PubMed publication ID

24 January 2017

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions (English)

1 reference

PubMed publication ID

24 January 2017

1 reference

GOA release 2020-03-11

Protein tyrosine phosphatase, non-receptor type 4

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GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

Rob Hooft van Huijsduijnen

8

object named as

Rob Hooft van Huijsduijnen

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PubMed publication ID

24 January 2017

author name string

Jennifer A. Young

1

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PubMed publication ID

24 January 2017

Amy M. Becker

2

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PubMed publication ID

24 January 2017

Jennifer J. Medeiros

3

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PubMed publication ID

24 January 2017

Virginia S. Shapiro

4

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PubMed publication ID

24 January 2017

Andrew Wang

5

1 reference

PubMed publication ID

24 January 2017

J. David Farrar

6

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PubMed publication ID

24 January 2017

Timothy A. Quill

7

1 reference

PubMed publication ID

24 January 2017

Nicolai S. C. van Oers

9

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PubMed publication ID

24 January 2017

publication date

1 August 2008

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PubMed publication ID

24 January 2017

Molecular Immunology

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PubMed publication ID

24 January 2017

45

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PubMed publication ID

24 January 2017

14

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PubMed publication ID

24 January 2017

3756–3766

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PubMed publication ID

24 January 2017

Protein tyrosine phosphatases and the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Protein tyrosine phosphatases in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Positive and negative regulation of T-cell activation through kinases and phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

NF-kappaB regulation in the immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

1 reference

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

1 reference

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19 March 2017

Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Molecular basis of T cell inactivation by CTLA-4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Involvement of Valosin-containing Protein, an ATPase Co-purified with IκBα and 26 S Proteasome, in Ubiquitin-Proteasome-mediated Degradation of IκBα

1 reference

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19 March 2017

Transcription factors of the NFAT family: regulation and function

1 reference

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19 March 2017

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Moesin: a member of the protein 4.1-talin-ezrin family of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

19 March 2017

ERM proteins and merlin: integrators at the cell cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

7 April 2017

Signal transduction by lymphocyte antigen receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

7 April 2017

The expanding role for ITAM-based signaling pathways in immune cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

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The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

1 reference

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29 September 2017

Role of ITAM-containing adapter proteins and their receptors in the immune system and bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

The CD3 gamma epsilon/delta epsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Relative contributions of NK and CD8 T cells to IFN-gamma mediated innate immune protection against Listeria monocytogenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

T cell receptor signaling: beyond complex complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

T-cell receptor signal transmission: who gives an ITAM?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Adaptors as central mediators of signal transduction in immune cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Negative regulation of immunoreceptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Combinatorial control of the specificity of protein tyrosine phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

The properties of the protein tyrosine phosphatase PTPMEG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Complex complexes: signaling at the TCR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Constitutive Tyrosine Phosphorylation of the T-Cell Receptor (TCR) ζ Subunit: Regulation of TCR-Associated Protein Tyrosine Kinase Activity by TCR ζ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Mechanistic aspects of NF-kappa B regulation: the emerging role of phosphorylation and proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Antigen receptors on B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

29 September 2017

Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

2 June 2018

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

2 June 2018

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

2 June 2018

Biochemical characterization of a human band 4.1-related protein-tyrosine phosphatase, PTPH1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

2 June 2018

Antigen receptor tail clue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

20 June 2018

Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

27 November 2018

Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

27 November 2018

Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

27 November 2018

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

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Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cells

1 reference

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Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

27 November 2018

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

27 November 2018

New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

27 November 2018

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596642

27 November 2018

Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12, but not IFN-alpha, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoskeletal protein tyrosine phosphatase PTPH1 reduces T cell antigen receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The constitutive tyrosine phosphorylation of CD3zeta results from TCR-MHC interactions that are independent of thymic selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18614237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.MOLIMM.2008.05.023

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PubMed publication ID

24 January 2017

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