Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice (Q28507303)

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English	Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice	scientific journal article

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24 January 2017

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5 January 2020

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice (English)

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24 January 2017

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5 January 2020

Fibroblast growth factor 23

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GOA release 2020-03-11

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5 January 2020

Harald Jüppner

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Harald Jüppner

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24 January 2017

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5 January 2020

Reinhold G Erben

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Reinhold G Erben

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5 January 2020

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Martina Hesse

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5 January 2020

Subbiah Yoganathan

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24 January 2017

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5 January 2020

Takashi Taguchi

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24 January 2017

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5 January 2020

Beate Lanske

8

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24 January 2017

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5 January 2020

Mohammed S Razzaque

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5 January 2020

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1 November 2004

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24 January 2017

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5 January 2020

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24 January 2017

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5 January 2020

23

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24 January 2017

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5 January 2020

7

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24 January 2017

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5 January 2020

421-432

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5 January 2020

Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

X-linked hypophosphataemia: a homologous disorder in humans and mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Etiology of hypercalcemia in hemodialysis patients on calcium carbonate therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

19 March 2017

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

7 April 2017

Developmental regulation of the growth plate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

7 April 2017

Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Fibroblast growth factor 23: a phosphatonin regulating phosphate homeostasis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

MEPE has the properties of an osteoblastic phosphatonin and minhibin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

The phosphatonin pathway: new insights in phosphate homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Cardiovascular disease in end-stage renal disease patients

1 reference

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29 September 2017

FGF23, hypophosphatemia, and rickets: has phosphatonin been found?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendations for a change in management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Intrinsic mineralization defect in Hyp mouse osteoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

29 September 2017

Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

2 June 2018

cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

2 June 2018

Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S.

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2 June 2018

The dialysis encephalopathy syndrome. Possible aluminum intoxication

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2 June 2018

FGF-23 in patients with end-stage renal disease on hemodialysis

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27 November 2018

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

27 November 2018

FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

27 November 2018

Serum FGF23 levels in normal and disordered phosphorus homeostasis.

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27 November 2018

Oncogenic osteomalacia--a complex dance of factors.

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27 November 2018

Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

27 November 2018

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression

1 reference

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27 November 2018

Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

27 November 2018

Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

27 November 2018

Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism

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27 November 2018

Octreotide therapy for tumor-induced osteomalacia

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27 November 2018

Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2894977

27 November 2018

Poly[allylamine hydrochloride] (RenaGel): a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure

1 reference

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27 November 2018

Calcium carbonate as a phosphate binder in patients with chronic renal failure undergoing dialysis

1 reference

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27 November 2018

Clinical case seminar: Fibroblast growth factor 23: a new clinical marker for oncogenic osteomalacia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15579309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15579309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Case 29-2001: Oncogenic Hypophosphatemic Osteomalacia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15579309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RenaGel, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone. The RenaGel Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/15579309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15579309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15579309

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.MATBIO.2004.09.007

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5 January 2020

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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5 January 2020

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Consolidated OpenCitations Corpus – April 2017

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5 January 2020

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