PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression (Q28505099)

24 January 2017

title

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression (English)

1 reference

Transformation related protein 53

24 January 2017

main subject

1 reference

Phosphatase and tensin homolog

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

0 references

Chun-Ju Chang

1 reference

24 January 2017

David J. Mulholland

1 reference

24 January 2017

Bahram Valamehr

1 reference

24 January 2017

Sherly Mosessian

1 reference

24 January 2017

William R. Sellers

1 reference

24 January 2017

Hong Wu

1 reference

24 January 2017

language of work or name

English

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publication date

1 May 2008

1 reference

Molecular and Cellular Biology

24 January 2017

published in

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24 January 2017

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24 January 2017

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24 January 2017

page(s)

3281–3289

1 reference

describes a project that uses

24 January 2017

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2423144/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Ubiquitination regulates PTEN nuclear import and tumor suppression

19 March 2017

1 reference

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Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs

19 March 2017

1 reference

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The biology and clinical relevance of the PTEN tumor suppressor pathway

19 March 2017

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PTEN: one gene, many syndromes

19 March 2017

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PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

19 March 2017

1 reference

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The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

19 March 2017

1 reference

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Phosphorylation of the PTEN tail regulates protein stability and function

19 March 2017

1 reference

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Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

19 March 2017

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A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast

19 March 2017

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

19 March 2017

1 reference

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Live or let die: the cell's response to p53

19 March 2017

1 reference

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A role for nuclear PTEN in neuronal differentiation.

7 April 2017

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The antioxidant function of the p53 tumor suppressor

7 April 2017

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Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade

7 April 2017

1 reference

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A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation

29 September 2017

1 reference

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Identification of a tumour suppressor network opposing nuclear Akt function

29 September 2017

1 reference

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Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta

29 September 2017

1 reference

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PTEN enters the nucleus by diffusion

29 September 2017

1 reference

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Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Regulation of PTEN by Rho small GTPases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Human cancer, PTEN and the PI-3 kinase pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Cellular response to oxidative stress: signaling for suicide and survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

The multiple roles of PTEN in tumor suppression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Diet, androgens, oxidative stress and prostate cancer susceptibility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Changes in endometrial PTEN expression throughout the human menstrual cycle

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Mechanistic insights into maintenance of high p53 acetylation by PTEN.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

PTEN regulates Mdm2 expression through the P1 promoter

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2423144

[PTEN tumor suppressor: functions as a lipid phosphatase]

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18332125

12 December 2020

inferred from PubMed ID database lookup

Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18332125

12 December 2020

inferred from PubMed ID database lookup

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/18332125

12 December 2020