Phase I clinical trial of systemically administered TUSC2(FUS1)-nanoparticles mediating functional gene transfer in humans (Q28482937)

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David J Stewart

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J Jack Lee

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Lin Ji

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Rajagopal Ramesh

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Gitanjali Jayachandran

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Maria I Nunez

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Jeremy J Erasmus

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Marshall E Hicks

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Elizabeth A Grimm

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James M Reuben

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Veerabhadran Baladandayuthapani

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Nancy S Templeton

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John D McMannis

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Jack A Roth

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2012

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e34833

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start time

25 April 2012

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer

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Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo

19 March 2017

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The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium

19 March 2017

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

19 March 2017

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Reporting results of cancer treatment

7 April 2017

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Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic

7 April 2017

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miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1.

29 September 2017

1 reference

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Tumor suppressor FUS1 signaling pathway

29 September 2017

1 reference

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Synergistic tumor suppression by coexpression of FUS1 and p53 is associated with down-regulation of murine double minute-2 and activation of the apoptotic protease-activating factor 1-dependent apoptotic pathway in human non-small cell lung cancer c

29 September 2017

1 reference

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Biomimetic amplification of nanoparticle homing to tumors

29 September 2017

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3p21.3 tumor suppressor cluster: prospects for translational applications

29 September 2017

1 reference

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Adenovirus p53 gene therapy

29 September 2017

1 reference

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Intrinsic tumour suppression

29 September 2017

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Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells

29 September 2017

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Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice

29 September 2017

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Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma

29 September 2017

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In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells

29 September 2017

1 reference

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Molecular themes in oncogenesis

29 September 2017

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Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

29 September 2017

1 reference

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Identification and removal of colanic acid from plasmid DNA preparations: implications for gene therapy

29 September 2017

1 reference

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Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma

2 June 2018

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Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA

2 June 2018

1 reference

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Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

2 June 2018

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Continual reassessment method: a practical design for phase 1 clinical trials in cancer

2 June 2018

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Improved DNA: liposome complexes for increased systemic delivery and gene expression

2 June 2018

1 reference

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Reversible mode of binding of serum proteins to DOTAP/cholesterol Lipoplexes: a possible explanation for intravenous lipofection efficiency

20 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034833

Increased uptake of liposomal-DNA complexes by lung metastases following intravenous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034833

Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034833

Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034833

The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034833

Bacterial DNA is implicated in the inflammatory response to delivery of DNA/DOTAP to mouse lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0034833

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22558101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Liposomal vector mediated delivery of the 3p FUS1 gene demonstrates potent antitumor activity against human lung cancer in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22558101

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0034833

1 reference

ADS bibcode

2012PLoSO...734833L

0 references

1 reference

1 reference

PubMed publication ID

22558101

1 reference