The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis (Q28485409)

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Shuyu Hao

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Benlian Wang

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Michael L Robinson

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Vincent M Monnier

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2012

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e50832

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start time

30 November 2012

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

19 March 2017

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The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage

19 March 2017

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Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells

19 March 2017

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Tight binding of proteins to membranes from older human cells.

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Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis

29 September 2017

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Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.

29 September 2017

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Lens aging: effects of crystallins

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Raman spectroscopic evidence for nuclear disulfide in isolated lenses of hyperbaric oxygen-treated guinea pigs

29 September 2017

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Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model

29 September 2017

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Accumulation of DNA, nuclear and mitochondrial debris, and ROS at sites of age-related cortical cataract in mice

29 September 2017

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Structure elucidation of a novel yellow chromophore from human lens protein

29 September 2017

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Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13

29 September 2017

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Quantitative screening of protein biomarkers of early glycation, advanced glycation, oxidation and nitrosation in cellular and extracellular proteins by tandem mass spectrometry multiple reaction monitoring

29 September 2017

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Glutathione: a vital lens antioxidant

29 September 2017

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Blindness due to cataract: epidemiology and prevention

29 September 2017

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Selective oxidation of cysteine and methionine in normal and senile cataractous lenses

29 September 2017

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Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage

29 September 2017

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High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis

29 September 2017

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Reaction of ascorbate with lysine and protein under autoxidizing conditions: formation of N epsilon-(carboxymethyl)lysine by reaction between lysine and products of autoxidation of ascorbate

29 September 2017

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Non-tryptophan fluorescence and high molecular weight protein formation in lens crystallins of rats with chronic galactosemia: prevention by the aldose reductase inhibitor sorbinil

2 June 2018

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Proteomic analysis of the oxidation of cysteine residues in human age-related nuclear cataract lenses

2 June 2018

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Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice

21 January 2018

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Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins

21 January 2018

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Tryptophan metabolites from young human lenses and the photooxidation of ascorbic acid by UVA light

21 January 2018

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Incidence of Age-Related Cataract over a 15-Year Interval

21 January 2018

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Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice

21 January 2018

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Molecular characterization of a reduced glutathione transporter in the lens

27 November 2018

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The Hydroxyl Radical in Lens Nuclear Cataractogenesis

27 November 2018

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12 December 2020

The contribution of GSH peroxidase-1, catalase and GSH to the degradation of H2O2 by the mouse lens

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12 December 2020

Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method

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12 December 2020

Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, alpha-crystallin, in maintaining lens flexibility

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12 December 2020

Cataract development in gamma-glutamyl transpeptidase-deficient mice

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12 December 2020

Lenticular glutathione synthesis: rate-limiting factors in its regulation and decline

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12 December 2020

Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice

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12 December 2020

Peroxide-induced effects on lens cation transport following inhibition of glutathione reductase activity in vitro

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12 December 2020

Characterization of disulfide-linked crystallins associated with human cataractous lens membranes

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12 December 2020

Effect of pigmentation on glutathione redox cycle antioxidant defense in whole as well as different regions of human cataractous lens

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12 December 2020

Peroxide-induced damage in lenses of transgenic mice with deficient and elevated levels of glutathione peroxidase

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12 December 2020

An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract

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12 December 2020

10.1371/JOURNAL.PONE.0050832

Identifiers

DOI

1 reference

ADS bibcode

2012PLoSO...750832F

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1 reference

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PubMed publication ID

23226398

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