An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer (Q28484295)

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Harsh B Pathak

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Hong Zhang

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Yan Zhou

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Margret B Einarson

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Vinod Vathipadiekal

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Sumedha Gunewardena

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Michael J Birrer

Creative Commons Attribution 4.0 International

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language of work or name

English

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publication date

2012

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e47086

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start time

9 October 2012

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Purified autoantibodies against glucose-regulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cells

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Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

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29 September 2017

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Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation

29 September 2017

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29 September 2017

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A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Pleiotrophin as a possible new target for angiogenesis-related diseases and cancer

29 September 2017

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Improved anti-tumor therapy based upon infectivity-enhanced adenoviral delivery of RNA interference in ovarian carcinoma cell lines

29 September 2017

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Synthetic lethal screen identification of chemosensitizer loci in cancer cells

29 September 2017

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Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis

29 September 2017

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BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation

29 September 2017

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Identification of the angiogenesis signaling domain in pleiotrophin defines a mechanism of the angiogenic switch

29 September 2017

1 reference

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Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies

29 September 2017

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Oncogenic pathways implicated in ovarian epithelial cancer

29 September 2017

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Inhibitory mechanisms of antibiotics targeting elongation factor Tu.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467214

Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467214

ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467214

Development of human tumor cell line panels for use in disease-oriented drug screening

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467214

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467214

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467214

Extraribosomal functions of ribosomal proteins.

2 June 2018

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Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells.

2 June 2018

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Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network

28 July 2018

1 reference

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Reverse transfection on cell arrays for high content screening microscopy.

27 November 2018

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Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation

27 November 2018

1 reference

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Elongation factor 2 as a target for selective inhibition of protein synthesis in vitro by the novel aromatic bisamidine.

27 November 2018

1 reference

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Reproductive risk factors for epithelial ovarian cancer according to histologic type and invasiveness

27 November 2018

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12 December 2020

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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12 December 2020

Telomere length changes in human cancer

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12 December 2020

Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms

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12 December 2020

Assessing the translatability of drug projects: what needs to be scored to predict success?

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12 December 2020

HARP induces angiogenesis in vivo and in vitro: implication of N or C terminal peptides

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12 December 2020

RNA Interference Advances to Early-Stage Clinical Trials

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12 December 2020

Targeted delivery of small interfering RNA to angiogenic endothelial cells with liposome-polycation-DNA particles

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12 December 2020

10.1371/JOURNAL.PONE.0047086

Identifiers

DOI

1 reference

ADS bibcode

2012PLoSO...747086S

0 references

1 reference

1 reference

PubMed publication ID

23056589

1 reference