Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor (Q28472108)

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English	Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor	scientific article

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13 February 2020

Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor (English)

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13 February 2020

desensitization

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Peter McCormick

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13 February 2020

Giovanna Tosato

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Giovanna Tosato

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13 February 2020

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Marta Segarra

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13 February 2020

Paola Gasperini

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13 February 2020

A Virginia Gulino

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13 February 2020

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1 December 2009

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13 February 2020

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13 February 2020

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13 February 2020

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13 February 2020

e8102

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13 February 2020

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1 December 2009

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0 references

A functional heteromeric MIF receptor formed by CD74 and CXCR4

1 reference

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19 March 2017

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling

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The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling

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19 March 2017

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4

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19 March 2017

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

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19 March 2017

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

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Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

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The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

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19 March 2017

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

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7 April 2017

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

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CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

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29 September 2017

CXCR4-CCR5: a couple modulating T cell functions

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Evolving concepts on the microenvironmental niche for hematopoietic stem cells

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29 September 2017

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.

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29 September 2017

Intracellular mediators of CXCR4-dependent signaling in T cells

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29 September 2017

G protein-coupled receptor sorting to endosomes and lysosomes

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29 September 2017

Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4.

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29 September 2017

Beta-arrestin-biased ligands at seven-transmembrane receptors

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29 September 2017

Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells

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29 September 2017

Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alpha

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29 September 2017

Regulation of CXCR4 signaling

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29 September 2017

G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells

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29 September 2017

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

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29 September 2017

Seven-transmembrane receptor signaling through beta-arrestin

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29 September 2017

CXCR4 mutations in WHIM syndrome: a misguided immune system?

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29 September 2017

Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma

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WHIM syndrome: a genetic disorder of leukocyte trafficking

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29 September 2017

Leukocyte-endothelium interaction promotes SDF-1-dependent polarization of CXCR4.

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29 September 2017

Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease

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29 September 2017

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

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29 September 2017

Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages

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WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

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Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome

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The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment

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Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1

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Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence

1 reference

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12 December 2020

based on heuristic

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10.1371/JOURNAL.PONE.0008102

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13 February 2020

2009PLoSO...4.8102M

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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13 February 2020

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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