Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma (Q28469179)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17425403%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma (English)

1 reference

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29 December 2019

0 references

1 reference

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29 December 2019

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29 December 2019

Todd R Golub

1 reference

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29 December 2019

Jenny S Wong

1 reference

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29 December 2019

Kenneth N Ross

1 reference

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29 December 2019

David Peck

1 reference

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29 December 2019

Renee D Wright

1 reference

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29 December 2019

Stephen L Lessnick

1 reference

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29 December 2019

Kimberly Stegmaier

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29 December 2019

language of work or name

English

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publication date

1 April 2007

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29 December 2019

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29 December 2019

volume

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29 December 2019

issue

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29 December 2019

page(s)

e122

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Creative Commons Attribution 4.0 International

29 December 2019

start time

10 April 2007

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma

1 reference

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Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

19 March 2017

1 reference

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19 March 2017

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19 March 2017

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The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

19 March 2017

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Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts

19 March 2017

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Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

19 March 2017

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A method for high-throughput gene expression signature analysis

19 March 2017

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High-dose cytosine arabinoside in the treatment of acute myeloid leukemia: Review of three randomized trials

29 September 2017

1 reference

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TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer

29 September 2017

1 reference

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

29 September 2017

1 reference

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Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation

29 September 2017

1 reference

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The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts

29 September 2017

1 reference

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Consolidation therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of cytosine arabinoside, epipodophyllotoxins and cyclophosphamide

29 September 2017

1 reference

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Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Clinical pharmacokinetics of nucleoside analogues: focus on haematological malignancies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Insulin-like growth factor-I-dependent growth and in vitro chemosensitivity of Ewing's sarcoma and peripheral primitive neuroectodermal tumour cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

2 June 2018

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Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene

2 June 2018

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A Ligase-Mediated Gene Detection Technique

2 June 2018

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NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma

2 June 2018

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Repetitive cycles of high-dose cytarabine are effective for childhood acute myeloid leukemia: long-term outcome of the children with AML treated on two consecutive trials of Tokyo Children's Cancer Study Group.

27 November 2018

1 reference

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The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide--a Children's Cancer Group and Pediatric Oncology Group study

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1851624

Enhanced detection and distinction of RNA by enzymatic probe ligation

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17425403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17425403

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PMED.0040122

2 references

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29 December 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17425403%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

17425403

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17425403%20AND%20SRC:MED&resulttype=core&format=json