A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches (Q28392033)

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English	A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches	scientific article

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instance of

scholarly article

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title

A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches (English)

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main subject

pathogenesis

1 reference

based on heuristic

inferred from title

cell function

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author

Michael Karin

series ordinal

3

object named as

Michael Karin

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David A. Brenner

object named as

David A Brenner

series ordinal

2

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author name string

Ekihiro Seki

series ordinal

1

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language of work or name

English

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publication date

August 2012

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published in

Gastroenterology

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volume

143

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issue

2

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page(s)

307-20

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cites work

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Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53

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Signal transduction by the JNK group of MAP kinases

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c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

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Functions of c-Jun in liver and heart development

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

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20 March 2017

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

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20 March 2017

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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20 March 2017

Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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TLR4 enhances TGF-beta signaling and hepatic fibrosis

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7 April 2017

A central role for JNK in obesity and insulin resistance

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7 April 2017

NF-kappaB at the crossroads of life and death

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7 April 2017

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice

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9 May 2017

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

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29 September 2017

Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation

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29 September 2017

The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival

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29 September 2017

Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes

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29 September 2017

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

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29 September 2017

The role of JNK in the development of hepatocellular carcinoma

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29 September 2017

Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice

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29 September 2017

Tumor necrosis factor α stimulates endothelin-1 synthesis in rat hepatic stellate cells in hepatic wound healing through a novel IKK/JNK pathway

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29 September 2017

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis

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29 September 2017

Endoplasmic reticulum stress in liver disease

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29 September 2017

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.

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29 September 2017

Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance

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29 September 2017

Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma

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29 September 2017

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

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29 September 2017

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1

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29 September 2017

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

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29 September 2017

Prevention of steatosis by hepatic JNK1

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29 September 2017

c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.

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29 September 2017

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice

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29 September 2017

Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance

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29 September 2017

Mcl-1 degradation during hepatocyte lipoapoptosis

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29 September 2017

JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis

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29 September 2017

Signal integration by JNK and p38 MAPK pathways in cancer development

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29 September 2017

c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice

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29 September 2017

Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase

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29 September 2017

Induction of hepatitis by JNK-mediated expression of TNF-alpha

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29 September 2017

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand

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29 September 2017

Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice

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29 September 2017

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

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29 September 2017

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

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29 September 2017

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

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29 September 2017

A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity

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29 September 2017

Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis

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29 September 2017

C-Jun N-terminal kinase 2 promotes graft injury via the mitochondrial permeability transition after mouse liver transplantation

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29 September 2017

Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2.

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29 September 2017

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury

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29 September 2017

JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation

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29 September 2017

Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase

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29 September 2017

Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury

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29 September 2017

TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death

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29 September 2017

Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases

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29 September 2017

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

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29 September 2017

TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

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29 September 2017

c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

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29 September 2017

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

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29 September 2017

Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

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29 September 2017

Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway

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PubMed Central

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29 September 2017

Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury

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29 September 2017

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

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29 September 2017

The future of GI and liver research: editorial perspectives. III. JNK/AP-1 regulation of hepatocyte death

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29 September 2017

Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver

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29 September 2017

NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun

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29 September 2017

Expression of c-Myc, c-Fos, and c-jun in hepatocellular carcinoma

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

29 September 2017

The regulation of AP-1 activity by mitogen-activated protein kinases

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

29 September 2017

Activation of Jun kinase is an early event in hepatic regeneration

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

29 September 2017

Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

29 September 2017

Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Transient induction of c-jun during hepatic regeneration

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

2 June 2018

Tumor necrosis factor-alpha accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

20 June 2018

Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Identification of small-molecule inhibitors of the JIP-JNK interaction.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Hepatocyte-specific inhibitor-of-kappaB-kinase deletion triggers the innate immune response and promotes earlier cell proliferation during liver regeneration.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

JNK mediates hepatic ischemia reperfusion injury

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Inhibition of JNK activation through NF-kappaB target genes

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3523093

retrieved

27 November 2018

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22705006

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22705006

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fructose selectively modulates c-jun N-terminal kinase activity and insulin signaling in rat primary hepatocytes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22705006

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22705006

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/22705006

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1053/J.GASTRO.2012.06.004

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

124923

OpenCitations bibliographic resource ID

124923

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

124923

PMC publication ID

3523093

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

124923

PubMed publication ID

22705006

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

124923

 

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