Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A (Q28387833)

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English	Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A	scientific article

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Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A (English)

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Shelly Kaushik

2

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object named as

Boon Chuan Low

5

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author name string

Archna Ravi

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Aarthi Ravichandran

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Catherine Qiurong Pan

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publication date

13 February 2015

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Journal of Biological Chemistry

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290

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7

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4149-62

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4326825/fullTextXML

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Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger

1 reference

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Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

1 reference

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20 March 2017

Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

1 reference

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Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

1 reference

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20 March 2017

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

1 reference

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20 March 2017

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

1 reference

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20 March 2017

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

1 reference

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20 March 2017

Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function

1 reference

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Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration

1 reference

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20 March 2017

DLC1: a significant GAP in the cancer genome

1 reference

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20 March 2017

DLC-1: a Rho GTPase-activating protein and tumour suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

20 March 2017

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

1 reference

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20 March 2017

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

1 reference

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20 March 2017

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

1 reference

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20 March 2017

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

20 March 2017

Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1

1 reference

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20 March 2017

Rho GTPases: biochemistry and biology

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

20 March 2017

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6 April 2017

Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma

1 reference

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20 March 2017

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

1 reference

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20 March 2017

A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

20 March 2017

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

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20 March 2017

Rho and Rac take center stage

1 reference

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20 March 2017

Environmental sensing through focal adhesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

7 April 2017

Focal adhesion kinase: in command and control of cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

7 April 2017

Functional atlas of the integrin adhesome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

7 April 2017

Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Control of motile and invasive cell phenotypes by focal adhesion kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Focal adhesion kinase is involved in mechanosensing during fibroblast migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Characterization of the PP2A alpha gene mutation in okadaic acid-resistant variants of CHO-K1 cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

29 September 2017

Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

2 June 2018

PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.

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2 June 2018

Overexpression of DLC-1 induces cell apoptosis and proliferation inhibition in the renal cell carcinoma

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https://api.crossref.org/works/10.1074%2FJBC.M114.616839

21 January 2018

Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading.

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https://api.crossref.org/works/10.1074%2FJBC.M114.616839

21 January 2018

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing.

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https://api.crossref.org/works/10.1074%2FJBC.M114.616839

21 January 2018

DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4326825

27 November 2018

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