Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation (Q28378559)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

12 May 2020

U Pirvola

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

12 May 2020

L Xing-Qun

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12 May 2020

J Virkkala

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12 May 2020

M Saarma

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

12 May 2020

C Murakata

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

12 May 2020

A M Camoratto

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

12 May 2020

K M Walton

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

12 May 2020

J Ylikoski

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12 May 2020

language of work or name

English

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publication date

1 January 2000

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published in

Journal of Neuroscience

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12 May 2020

volume

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12 May 2020

issue

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12 May 2020

page(s)

43-50

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Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

12 May 2020

cites work

1 reference

12 December 2020

A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion

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12 December 2020

Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment.

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12 December 2020

Reactive oxygen species in chick hair cells after gentamicin exposure in vitro

1 reference

12 December 2020

CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo

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12 December 2020

Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex

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12 December 2020

Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway

1 reference

12 December 2020

Role of glutathione in protection against noise-induced hearing loss

1 reference

12 December 2020

Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma

1 reference

12 December 2020

The structural and functional consequences of acoustic injury in the cochlea and peripheral auditory system: a five year update

1 reference

12 December 2020

N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss

1 reference

12 December 2020

Therapeutic potential of neurotrophic factors for neurological disorders

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12 December 2020

Amikacin intoxication induces apoptosis and cell proliferation in rat organ of Corti

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12 December 2020

GDNF protects the cochlea against noise damage

1 reference

12 December 2020

Changes in stereocilia micromechanics following overstimulation in metabolically blocked hair cells

1 reference

12 December 2020

Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts

1 reference

12 December 2020

A cytoplasmic inhibitor of the JNK signal transduction pathway

1 reference

12 December 2020

Time sequence of degeneration pattern of the organ of Corti after acoustic overstimulation. A light microscopical and electrophysiological investigation in the guinea pig

1 reference

12 December 2020

Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3.

1 reference

12 December 2020

Molecular mechanisms of developmental neuronal death

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12 December 2020

Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment

1 reference

12 December 2020

Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

1 reference

12 December 2020

Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants

1 reference

12 December 2020

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

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12 December 2020

Effects of BDNF and NT-3 on hair cell survival in guinea pig cochlea damaged by kanamycin treatment

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12 December 2020

Oxygen radicals and signaling

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12 December 2020

Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid

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12 December 2020

1 reference

12 December 2020

BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons

1 reference

12 December 2020

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

12 December 2020

Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells.

1 reference

12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

12 December 2020

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

1 reference

12 December 2020

R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla

1 reference

12 December 2020

Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla

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12 December 2020

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

1 reference

12 December 2020

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

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12 December 2020

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

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12 December 2020

Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons.

1 reference

12 December 2020

Functional role of the olivo-cochlear bundle: a motor unit control system in the mammalian cochlea

1 reference

12 December 2020

Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis.

1 reference

12 December 2020

Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear.

1 reference

12 December 2020

Guinea-Pig Hair Cell Pathology from Ototoxic Antibiotics

1 reference

12 December 2020

CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.

1 reference

12 December 2020

Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro

1 reference

12 December 2020

Potentiation of ototoxicity by glutathione depletion

1 reference

12 December 2020

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

12 December 2020

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

12 December 2020

Acoustic trauma and cochlear microcirculation. An experimental and clinical study on pathogenesis and treatment of inner ear lesions after acute noise exposure

1 reference

12 December 2020

CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.

1 reference

12 December 2020

10.1523/JNEUROSCI.20-01-00043.2000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

release_s3ulcdv4fjcofms2yfl32hct5q

12 May 2020

Fatcat ID

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json

12 May 2020

PubMed publication ID

10627579

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6774096&resulttype=core&format=json